Is there a role for CEA in innate immunity in the colon?
2001 (English)In: Trends in Microbiology, ISSN 0966-842X, E-ISSN 1878-4380, Vol. 9, no 3, 119-25 p.Article in journal (Refereed) Published
Carcinoembryonic antigen (CEA) is a well known tumor marker associated with the progression of colorectal tumors. The CEA family of glycoproteins has been fully characterized and the function of some of its members is now beginning to be understood. Here, we advance the hypothesis that, rather than functioning in cell adhesion as has been suggested previously, CEA plays a role in protecting the colonic mucosa from microbial invasion. This hypothesis is based on new microscopic, molecular, phylogenetic and microbiological evidence.
Place, publisher, year, edition, pages
2001. Vol. 9, no 3, 119-25 p.
Biochemistry and Molecular Biology Microbiology
IdentifiersURN: urn:nbn:se:umu:diva-67881PubMedID: 11239789OAI: oai:DiVA.org:umu-67881DiVA: diva2:614760