H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis
2013 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 34, no 5, 1517.e5-1517.e7 p.Article in journal (Refereed) Published
The H63D polymorphism in HFE has frequently been associated with susceptibility to amyotrophic lateral sclerosis (ALS). Regarding the role of HFE in iron homeostasis, iron accumulation is considered an important process in ALS. Furthermore, novel therapeutic strategies are being developed targeting this process. Evidence for this genetic association is, however, limited to several small studies. For this reason we studied the H63D polymorphism in a large European cohort including 3962 ALS patients and 5072 control subjects from 7 countries. After meta-analysis of previous studies and current findings we conclude that the H63D polymorphism in HFE is not associated with susceptibility to ALS, age at disease onset, or survival. (C) 2013 Elsevier Inc. All rights reserved.
Place, publisher, year, edition, pages
2013. Vol. 34, no 5, 1517.e5-1517.e7 p.
Amyotrophic lateral sclerosis (ALS), Motor neuron disease (MND), HFE, H63D, rs1799945
IdentifiersURN: urn:nbn:se:umu:diva-67952DOI: 10.1016/j.neurobiolaging.2012.07.020ISI: 000315729500023OAI: oai:DiVA.org:umu-67952DiVA: diva2:616038