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Different occurrence of CD8+, CD45R0+, and CD68+ immune cells in regional lymph node metastases from colorectal cancer as potential prognostic predictors
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
2002 (English)In: International Journal of Colorectal Disease, ISSN 0179-1958, E-ISSN 1432-1262, Vol. 17, no 1, 25-29 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND AIMS: To study whether there are differences in the immunohistochemical staining of CD8, CD45R0, and CD68 of immune cells in regional lymph node metastases from colorectal cancer that are of potential interest in prognostic prediction.

MATERIALS AND METHODS: Analysis of archival specimens from 93 patients operated on for colorectal cancer (based on monoclonal antibodies, the ABC technique, and semiquantitative classification).

RESULTS: There was a significant difference in survival time between patients with respect to the number of positive immune cells. The cancer-specific 5-year survival rate was 77% for patients with high numbers of CD8+ cells, compared to 33% for those with lower numbers. The corresponding figures for patients with CD45R0+ cells were 66% vs. 33%, and for patients with CD68+ cells 60% vs. 38%. Significant differences remained among the 74 patients without adjuvant radio/chemotherapy regarding CD8 and CD45R0 but not CD68.

CONCLUSION: The presence of CD8+, CD45R0+, and CD68+ immune cells in regional lymph node metastases may serve as predictors of patients survival in colorectal cancer Dukes' stage C.

Place, publisher, year, edition, pages
Springer, 2002. Vol. 17, no 1, 25-29 p.
National Category
Gastroenterology and Hepatology Surgery
Identifiers
URN: urn:nbn:se:umu:diva-68362DOI: 10.1007/s003840100337PubMedID: 12018450OAI: oai:DiVA.org:umu-68362DiVA: diva2:616584
Available from: 2013-04-17 Created: 2013-04-17 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Prognostic factors in colorectal cancer: aspects of tumour dissemination
Open this publication in new window or tab >>Prognostic factors in colorectal cancer: aspects of tumour dissemination
2002 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå Universitet, 2002. 61 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 798
Keyword
Colorectal neoplasms, prognosis, lymph node metastases, disseminated tumour cells, cytokeratins, micrometastases, metalloproteinases, immune cells, real-time quantitative RT-PCR, carsinoembryonic antigen
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-94103 (URN)91-7305-264-7 (ISBN)
Public defence
2002-09-20, Tandläkarhögskolan, Sal B, 9 tr., Umeå universitet, Umeå, 09:00
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digitalisering@umu
Note

Diss. (sammanfattning) Umeå : Umeå universitet, 2002

Available from: 2014-11-19 Created: 2014-10-03 Last updated: 2015-04-10Bibliographically approved

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