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Are lymph node micrometastases of any clinical significance in Dukes' stages A and B colorectal cancer?
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Radiation Sciences, Oncology.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
1998 (English)In: Diseases of the Colon & Rectum, ISSN 0012-3706, E-ISSN 1530-0358, Vol. 41, no 10, 1244-1249 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: The aim was to investigate the significance of lymph node micrometastases in Dukes Stages A and B colorectal cancer.

METHODS: Archival specimens were examined from 147 patients (96 colon, 51 rectum; 44 Stage A, 103 Stage B) who had surgery between 1987 and 1994. One lymph node section from each node (colon, 1-11; median, 4; rectum, 1-15; median, 3) was examined with use of an anticytokeratin antibody.

RESULTS: Forty-seven (32 percent) patients had micrometastases. At follow-up in June 1996, 23 patients had died of cancer or with known tumor relapse, after a median time of 28 (range, 5-67) months; 8 of 47 (17 percent) patients had micrometastases, 15 of 100 (15 percent) did not. No statistically significant differences were observed according to micrometastases when the results were analyzed with respect to Dukes stage or survival time. The median survival time of living patients with micrometastases was 48 (range, 18-97) months, and for patients without micrometastases, 48 (range, 19-111) months. Six of 96 living patients had a tumor relapse; three of these displayed micrometastases.

CONCLUSION: Lymph node micrometastases are not a useful prognostic marker in Dukes Stages A and B and do not imply different strategies for additional therapy or follow-up.

Place, publisher, year, edition, pages
Wolters Kluwer, 1998. Vol. 41, no 10, 1244-1249 p.
Keyword [en]
Colonic neoplasms, Cytokeratin, Immunohistochemistry, Lymph nodes, Micrometastases, Rectal neoplasms, Survival, Tumor stage
National Category
Gastroenterology and Hepatology Surgery
Identifiers
URN: urn:nbn:se:umu:diva-68360DOI: 10.1007/BF02258221PubMedID: 9788387OAI: oai:DiVA.org:umu-68360DiVA: diva2:616591
Projects
digitalisering@umu
Available from: 2013-04-17 Created: 2013-04-17 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Prognostic factors in colorectal cancer: aspects of tumour dissemination
Open this publication in new window or tab >>Prognostic factors in colorectal cancer: aspects of tumour dissemination
2002 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Umeå: Umeå Universitet, 2002. 61 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 798
Keyword
Colorectal neoplasms, prognosis, lymph node metastases, disseminated tumour cells, cytokeratins, micrometastases, metalloproteinases, immune cells, real-time quantitative RT-PCR, carsinoembryonic antigen
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:umu:diva-94103 (URN)91-7305-264-7 (ISBN)
Public defence
2002-09-20, Tandläkarhögskolan, Sal B, 9 tr., Umeå universitet, Umeå, 09:00
Opponent
Supervisors
Projects
digitalisering@umu
Note

Diss. (sammanfattning) Umeå : Umeå universitet, 2002

Available from: 2014-11-19 Created: 2014-10-03 Last updated: 2015-04-10Bibliographically approved

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