Change search
ReferencesLink to record
Permanent link

Direct link
Fatigue in COPD and the Impact of Respiratory Symptoms and Heart Disease: A Population-based Study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Medicine.
2013 (English)In: COPD: Journal of Chronic Obstructive Pulmonary Disease, ISSN 1541-2555, Vol. 10, no 2, 125-132 p.Article in journal (Refereed) Published
Abstract [en]

Background: Fatigue is reported in COPD and in heart disease; however, there are hardly any population based data on the relationship between these conditions. Aim: To describe fatigue in relation to COPD by disease severity and to evaluate the impact of respiratory symptoms and heart disease. Methods: Data were collected in 2007 from the OLIN COPD study; 564 subjects with COPD (FEV1/FVC < 0.70) and a distribution of disease severity representative for the general population, and 786 subjects without COPD. The Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale was used to assess fatigue (0-52); lower scores represent worse fatigue. Results: Median FACIT-F score was 44.0 in COPD defined by merely spirometric criteria and 42.0 in COPD also reporting respiratory symptoms, significantly lower compared to 46.0 in non-COPD (p = 0.006 and p < 0.001), and decreased by disease severity. The score was lower in COPD stage >= II and in COPD with respiratory symptoms already from stage I when compared to non-COPD. Subjects with heart disease reported lower scores than those without heart disease in COPD by all stages and in non-COPD. COPD with respiratory symptoms stage >= II remained a significant risk factor for clinically significant fatigue also when adjusted for gender, age, heart disease and smoking habits (stage II OR 1.65, CI 1.17-2.31 and stage III-IV OR 2.66, CI 1.11-6.36). Conclusion: Fatigue is common in COPD, and is affected by respiratory symptoms and concomitant heart disease. In COPD with respiratory symptoms stage >= II, there is an increased risk for clinically significant fatigue.

Place, publisher, year, edition, pages
London: Informa Healthcare, 2013. Vol. 10, no 2, 125-132 p.
Keyword [en]
Comorbidity, Dyspnea, Pulmonary Rehabilitation, Risk Factors, Quality-of-Life
National Category
Public Health, Global Health, Social Medicine and Epidemiology
URN: urn:nbn:se:umu:diva-70140DOI: 10.3109/15412555.2012.728642ISI: 000316954500002OAI: diva2:620627
Available from: 2013-05-09 Created: 2013-05-06 Last updated: 2013-05-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Lindberg, Anne
By organisation
In the same journal
COPD: Journal of Chronic Obstructive Pulmonary Disease
Public Health, Global Health, Social Medicine and Epidemiology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 46 hits
ReferencesLink to record
Permanent link

Direct link