umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Pre- and postsynaptic dopamine SPECT in idiopathic parkinsonian diseases: a follow-up study
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Diagnostisk radiologi.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.
Umeå universitet, Samhällsvetenskapliga fakulteten, Handelshögskolan vid Umeå universitet, Statistik.
Visa övriga samt affilieringar
2013 (Engelska)Ingår i: BioMed Research International, ISSN 2314-6141, Vol. 2013, s. 143532-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

We prospectively evaluated the diagnostic contribution of 123I-FP-Cit (DAT) and 123I-IBZM (IBZM) SPECT in 29 patients with Parkinson’s disease (PD) (74.4 ± 4.2 years) and 28 patients with atypical parkinsonian diseases (APD) (74.3 ± 9.2 years). Twelve had multiple system atrophy (MSA) and 16 progressive supranuclear palsy (PSP). Sixteen age-matched healthy controls (HC) were included. DAT and IBZM SPECTs were made at baseline and after 1 year in all PD patients and in 20 (DAT) and 18 (IBZM) of the APD patients, and after 3 years in 22 (DAT) and 17 (IBZM) of the PD patients and in 10 (DAT) and 10 (IBZM) of the APD patients. The relative DAT uptake decrease was faster in PD and PSP than in HC and MSA. In PSP the DAT uptake was lower than in MSA after 1 year but not after 3 years. Baseline IBZM uptake was not significantly different between patients and HC or between PD and APD. One year after initiated dopaminergic treatment the mean IBZM uptake in the MSA patients remained high compared to PSP and after 3 years compared to PD, PSP, and HC.Thus, the pattern of uptake of these ligands over time may be of value in discriminating between these diagnoses.

Ort, förlag, år, upplaga, sidor
2013. Vol. 2013, s. 143532-
Nyckelord [en]
Parkinson’s disease, Multiple System Atrophy, Progressive Supranuclear Palsy, SPECT, 123I-FP-Cit, 123I-IBZM, prospective study
Nationell ämneskategori
Radiologi och bildbehandling
Forskningsämne
radiologi
Identifikatorer
URN: urn:nbn:se:umu:diva-70274DOI: 10.1155/2013/143532ISI: 000324939000001PubMedID: 24163811OAI: oai:DiVA.org:umu-70274DiVA, id: diva2:620927
Projekt
NYPUMPROSPUM
Anmärkning

Originally published in thesis in manuscript form

Tillgänglig från: 2013-05-12 Skapad: 2013-05-12 Senast uppdaterad: 2018-06-08Bibliografiskt granskad
Ingår i avhandling
1. Nuclear medicine methods in idiopathic Parkinsonism: pre- and postsynaptic dopamine SPECT
Öppna denna publikation i ny flik eller fönster >>Nuclear medicine methods in idiopathic Parkinsonism: pre- and postsynaptic dopamine SPECT
2013 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Alternativ titel[sv]
Nuklearmedicinska metoder vid idiopatisk Parkinsonism : pre- och postsynaptisk dopamin SPECT
Abstract [en]

Background: Single photon emission computed tomography (SPECT) with dopamine transporter (DAT) and dopamine D2 receptor (D2R) ligands can visualise the integrity of the nigrostriatal dopamine system. Parkinson’s disease (PD) and the atypical parkinsonian diseases (APD), progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), have similar symptoms and dopamine depletion, but differ in pharmacological response and prognosis. Clinical differentiation between PD and APD is often difficult in the early stages. The aims of the thesis were to evaluate the differential diagnostic and prognostic value of SPECT in early PD, MSA and PSP, to map the pattern of progression with dopamine SPECT, and map the pattern of dopamine SPECT in non-affected elderly volunteers with a prospective approach. Also, we evaluated the methodological aspects of dopamine SPECT with respect to image evaluation tools, reconstruction parameters and gamma cameras.

Methods: 172 patients, included in an on-going clinical prospective study on idiopathic parkinsonism, participated in the SPECT study. Also, 31 age-matched healthy controls (HC) were followed within this study. SPECT was done with 123I-FP-Cit (DAT SPECT) and 123I-IBZM (D2R SPECT). Regions of interest (ROI) were used as a standard method for semi-quantitative image analysis.

Results: SPECT uptake ratios from different gamma cameras could be equalised through correction equations derived from images of a brain-like phantom, provided that attenuation correction was applied. The ROI method had high reproducibility. SPECT uptake  in HC, measured with the ROI method and a volume based (VOI) method rendered similar trends, but gender and age differences in SPECT uptake were more marked with the VOI method, and less pronounced in DAT SPECT compared to D2R SPECT with both methods. The DAT SPECT uptake was significantly reduced in very early disease stage of PD and APD compared to HC. DATSPECT uptake was more reduced in PD with postural and gait disturbance (PIGD) compared to tremor-dominant PD. Decline in DAT SPECT uptake during the first year was more pronounced in PD and PSP compared to HC. D2R SPECT uptake overlapped between untreated PD and APD. After initiated treatment, the D2R SPECT uptake was significantly higher in MSA patients compared to PD, PSP and HC. Decline in D2R SPECT uptake during the first year was not significantly different between patients or compared to HC.

Conclusions: 123I-FP-Cit SPECT is a valuable and sensitive method to detect early stage idiopathic parkinsonism. A different level of uptake between PIGD-PD compared to TD-PD indicates a prognostic potential. It is not possible to differ between PD, MSA and PSP in early stage with 123I-FP-Cit SPECT and no differential diagnostic value was found using 123I-IBZM SPECT in the early, untreated stage of PD, MSA and PSP. A different pattern of uptake of this ligand in MSA compared to PD and PSP during the first years of L-dopa treatment may, however, indicate a diagnostic value during the follow-up period.

Ort, förlag, år, upplaga, sidor
Umeå: Umeå Universitet, 2013. s. 69
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1550
Nyckelord
Nuclear medicine, SPECT, 123I-FP-Cit, 123I-IBZM, dopamine, parkinsonism, Parkinson’s disease, multiple system atrophy, progressive supranuclear palsy
Nationell ämneskategori
Radiologi och bildbehandling
Forskningsämne
radiologi
Identifikatorer
urn:nbn:se:umu:diva-70275 (URN)978-91-7459-557-4 (ISBN)978-91-7459-646-5 (ISBN)
Disputation
2013-06-05, Sal 206, byggnad 3A, Norrlands Universitetssjukhus, Umeå, 09:00 (Svenska)
Opponent
Handledare
Tillgänglig från: 2013-05-15 Skapad: 2013-05-12 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

Open Access i DiVA

Pre- and postsynaptic dopamine SPECT in idiopathic parkinsonian diseases: a follow-up study(1909 kB)512 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1909 kBChecksumma SHA-512
93ab02af49fed5316afdc7487c28221a79c432024c45b5c40b6e6065b2e26944649d6e9fb954c63b259e1b557c005e83dd64fcdbb8a5ce3ff09389d8a7db9930
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Jakobson Mo, SusannaLinder, JanForsgren, LarsLarsson, AnneRiklund, Katrine

Sök vidare i DiVA

Av författaren/redaktören
Jakobson Mo, SusannaLinder, JanForsgren, LarsLarsson, AnneRiklund, Katrine
Av organisationen
Diagnostisk radiologiKlinisk neurovetenskapStatistikRadiofysik
Radiologi och bildbehandling

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 512 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 350 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf