Brief but Chronic Increase in Allopregnanolone Cause Accelerated AD Pathology Differently in Two Mouse Models
2013 (English)In: Current Alzheimer Research, ISSN 1567-2050, Vol. 10, no 1, 38-47 p.Article in journal (Refereed) Published
Previously, we have shown that chronic treatment with allopregnanolone (ALLO) for three months impaired learning function in the Swe/PS1 mouse model. ALLO is a neurosteroid, produced in the CNS and a GABA(A) receptor agonist. ALLO modulates the general inhibitory system in the CNS by enhancing the effect of GABA. Chronic treatment with other GABA(A) receptor active compounds, such as benzodiazepines, ethanol and medroxy-progesterone acetate has been associated to cognitive decline and/or increased risk for dementia. In this study, we sufficed with a treatment period of one month for the Swe/PS1 mouse, and included another Alzheimer's disease mouse model; the Swe/Arc model. We found that one month of chronic treatment with elevated ALLO levels within physiological range impaired learning and memory function in the Swe/Arc female and male mice. Male Swe/PS1 mice also showed marginally impaired function, while the female mice did not. Furthermore, the chronic ALLO treatment caused increased levels of soluble A beta in the Swe/PS1 mouse model while the levels were unchanged in the Swe/Arc model. Therefore, both Swe/Arc and Swe/PS1 mice showed signs of accelerated disease progression. Still, further studies are required to determine the mechanisms behind the cognitive impairment and the increased A beta-levels caused by mildly elevated ALLO-levels.
Place, publisher, year, edition, pages
Bentham Science Publishers , 2013. Vol. 10, no 1, 38-47 p.
Allopregnanolone, Alzheimer's disease, beta-amyloid(1-42), beta-amyloid(1-40), cognition, physiological stress, transgenic
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-70364DOI: 10.2174/156720513804871363ISI: 000317271800006OAI: oai:DiVA.org:umu-70364DiVA: diva2:621645