Evaluation of an attenuation correction method for PET/MR imaging of the head based on substitute CT images
2013 (English)In: Magnetic Resonance Materials in Physics, Biology and Medicine, ISSN 0968-5243, E-ISSN 1352-8661, Vol. 26, no 1, 127-136 p.Article in journal (Refereed) Published
The aim of this study was to evaluate MR-based attenuation correction of PET emission data of the head, based on a previously described technique that calculates substitute CT (sCT) images from a set of MR images. Images from eight patients, examined with F-18-FLT PET/CT and MRI, were included. sCT images were calculated and co-registered to the corresponding CT images, and transferred to the PET/CT scanner for reconstruction. The new reconstructions were then compared with the originals. The effect of replacing bone with soft tissue in the sCT-images was also evaluated. The average relative difference between the sCT-corrected PET images and the CT-corrected PET images was 1.6 % for the head and 1.9 % for the brain. The average standard deviations of the relative differences within the head were relatively high, at 13.2 %, primarily because of large differences in the nasal septa region. For the brain, the average standard deviation was lower, 4.1 %. The global average difference in the head when replacing bone with soft tissue was 11 %. The method presented here has a high rate of accuracy, but high-precision quantitative imaging of the nasal septa region is not possible at the moment.
Place, publisher, year, edition, pages
2013. Vol. 26, no 1, 127-136 p.
PET/MR, Attenuation correction, Substitute CT, F-18-FLT, UTE
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:umu:diva-67601DOI: 10.1007/s10334-012-0339-2ISI: 000314888300011OAI: oai:DiVA.org:umu-67601DiVA: diva2:624844