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Long term peripheral nerve regeneration using a novel PCL nerve conduit
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy. University of Manchester.
University of Manchester.
University of Manchester.
University of Manchester.
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2013 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 544, 125-30 p.Article in journal (Refereed) Published
Abstract [en]

The gold standard in surgical management of a peripheral nerve gap is currently autologous nerve grafting. This confers patient morbidity and increases surgical time therefore innovative experimental strategies towards engineering a synthetic nerve conduit are welcome. We have developed a novel synthetic conduit made of poly ε-caprolactone (PCL) that has demonstrated promising peripheral nerve regeneration in short-term studies. This material has been engineered to permit translation into clinical practice and here we demonstrate that histological outcomes in a long-term in vivo experiment are comparable with that of autologous nerve grafting. A 1cm nerve gap in a rat sciatic nerve injury model was repaired with a PCL nerve conduit or an autologous nerve graft. At 18 weeks post surgical repair, there was a similar volume of regenerating axons within the nerve autograft and PCL conduit repair groups, and similar numbers of myelinated axons in the distal stump of both groups. Furthermore, there was evidence of comparable re-innervation of end organ muscle and skin with the only significant difference the lower wet weight of the muscle from the PCL conduit nerve repair group. This study stimulates further work on the potential use of this synthetic biodegradable PCL nerve conduit in a clinical setting.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 544, 125-30 p.
Keyword [en]
Nerve regeneration, Biomaterial, Nerve conduit, Peripheral nerve, Poly ε-caprolactone
National Category
URN: urn:nbn:se:umu:diva-73224DOI: 10.1016/j.neulet.2013.04.001ISI: 000320632300025PubMedID: 23583695OAI: diva2:630468
Swedish Research Council

Funding Agencies:

National Institute for Health Research, Academy of Medical Sciences

British Society for Surgery of the Hand

Newby Trust 

Available from: 2013-06-19 Created: 2013-06-19 Last updated: 2013-10-31Bibliographically approved

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