Change search
ReferencesLink to record
Permanent link

Direct link
Brain Characteristics of Individuals Resisting Age-Related Cognitive Decline over Two Decades
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology. Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Medicine, Umeå Centre for Functional Brain Imaging (UFBI).
Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.
Umeå University, Faculty of Social Sciences, Department of Statistics.
Show others and affiliations
2013 (English)In: Journal of Neuroscience, ISSN 0270-6474, E-ISSN 1529-2401, Vol. 33, no 20, 8668-8677 p.Article in journal (Refereed) Published
Abstract [en]

Some elderly appear to resist age-related decline in cognitive functions, but the neural correlates of successful cognitive aging are not well known. Here, older human participants from a longitudinal study were classified as successful or average relative to the mean attrition-corrected cognitive development across 15-20 years in a population-based sample (n = 1561). Fifty-one successful elderly and 51 age-matched average elderly (mean age: 68.8 years) underwent functional magnetic resonance imaging while performing an episodic memory face-name paired-associates task. Successful older participants had higher BOLD signal during encoding than average participants, notably in the bilateral PFC and the left hippocampus (HC). The HC activation of the average, but not the successful, older group was lower than that of a young reference group (n = 45, mean age: 35.3 years). HC activation was correlated with task performance, thus likely contributing to the superior memory performance of successful older participants. The frontal BOLD response pattern might reflect individual differences present from young age. Additional analyses confirmed that both the initial cognitive level and the slope of cognitive change across the longitudinal measurement period contributed to the observed group differences in BOLD signal. Further, the differences between the older groups could not be accounted for by differences in brain structure. The current results suggest that one mechanism behind successful cognitive aging might be preservation of HC function combined with a high frontal responsivity. These findings highlight sources for heterogeneity in cognitive aging and may hold useful information for cognitive intervention studies.

Place, publisher, year, edition, pages
2013. Vol. 33, no 20, 8668-8677 p.
National Category
Basic Medicine
URN: urn:nbn:se:umu:diva-73534DOI: 10.1523/JNEUROSCI.2900-12.2013ISI: 000319112600009PubMedID: 23678111OAI: diva2:632429
Available from: 2013-06-25 Created: 2013-06-25 Last updated: 2013-11-04Bibliographically approved
In thesis
1. Attrition in Studies of Cognitive Aging
Open this publication in new window or tab >>Attrition in Studies of Cognitive Aging
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Alternative title[sv]
Bortfall i studier av kognitivt åldrande
Abstract [en]

Longitudinal studies of cognition are preferred to cross-sectional stud- ies, since they offer a direct assessment of age-related cognitive change (within-person change). Statistical methods for analyzing age-related change are widely available. There are, however, a number of challenges accompanying such analyzes, including cohort differences, ceiling- and floor effects, and attrition. These difficulties challenge the analyst and puts stringent requirements on the statistical method being used.

The objective of Paper I is to develop a classifying method to study discrepancies in age-related cognitive change. The method needs to take into account the complex issues accompanying studies of cognitive aging, and specifically work out issues related to attrition. In a second step, we aim to identify predictors explaining stability or decline in cognitive performance in relation to demographic, life-style, health-related, and genetic factors.

In the second paper, which is a continuation of Paper I, we investigate brain characteristics, structural and functional, that differ between suc- cessful aging elderly and elderly with an average cognitive performance over 15-20 years.

In Paper III we develop a Bayesian model to estimate the causal effect of living arrangement (living alone versus living with someone) on cog- nitive decline. The model must balance confounding variables between the two living arrangement groups as well as account for non-ignorable attrition. This is achieved by combining propensity score matching with a pattern mixture model for longitudinal data.

In paper IV, the objective is to adapt and implement available impu- tation methods to longitudinal fMRI data, where some subjects are lost to follow-up. We apply these missing data methods to a real dataset, and evaluate these methods in a simulation study.

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2013. 21 p.
Statistical studies, ISSN 1100-8989 ; 47
Attrition, missing data, age-related cognitive change, non- ignorable dropout, monotone missing pattern, mixture models, pattern- mixture models, imputation
National Category
Other Social Sciences not elsewhere specified
Research subject
urn:nbn:se:umu:diva-82514 (URN)978-91-7459-760-8 (ISBN)
Public defence
2013-11-29, Humanisthuset, Hörsal F, Umeå universitet, Umeå, 10:15 (English)
Available from: 2013-11-08 Created: 2013-11-04 Last updated: 2016-03-07Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Pudas, SaraPersson, JonasJosefsson, Mariade Luna, XavierNilsson, Lars-GöranNyberg, Lars
By organisation
PhysiologyUmeå Centre for Functional Brain Imaging (UFBI)StatisticsDepartment of StatisticsDiagnostic RadiologyDepartment of Radiation Sciences
In the same journal
Journal of Neuroscience
Basic Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 172 hits
ReferencesLink to record
Permanent link

Direct link