Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest
2013 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 54, no 23, 2989-2995 p.Article in journal (Refereed) Published
The coupling of o-bromobenzoic acid with terminal alkynes using 10% Pd/C-Et3N-CuI-PPh3 as a catalyst system leads to the synthesis of (Z)-3-alkylidenephthalides as the major product along with the traces of isocoumarin when the reaction was performed in 1,4-dioxane. The methodology afforded a range of compounds including (Z)-3-(4-(methylsulfonyl)benzylidene)isobenzofuran-1(3H)-one of potential pharmacological interest. (C) 2013 Elsevier Ltd. All rights reserved.
Place, publisher, year, edition, pages
Oxford, England: PERGAMON-ELSEVIER SCIENCE LTD , 2013. Vol. 54, no 23, 2989-2995 p.
Chemical Sciences Organic Chemistry
IdentifiersURN: urn:nbn:se:umu:diva-73557DOI: 10.1016/j.tetlet.2013.03.121ISI: 000318832200023OAI: oai:DiVA.org:umu-73557DiVA: diva2:632933