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Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest
Umeå University, Faculty of Science and Technology, Department of Chemistry.
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2013 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1359-8562, Vol. 54, no 23, 2989-2995 p.Article in journal (Refereed) Published
Abstract [en]

The coupling of o-bromobenzoic acid with terminal alkynes using 10% Pd/C-Et3N-CuI-PPh3 as a catalyst system leads to the synthesis of (Z)-3-alkylidenephthalides as the major product along with the traces of isocoumarin when the reaction was performed in 1,4-dioxane. The methodology afforded a range of compounds including (Z)-3-(4-(methylsulfonyl)benzylidene)isobenzofuran-1(3H)-one of potential pharmacological interest. (C) 2013 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
Oxford, England: PERGAMON-ELSEVIER SCIENCE LTD , 2013. Vol. 54, no 23, 2989-2995 p.
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Chemical Sciences Organic Chemistry
Identifiers
URN: urn:nbn:se:umu:diva-73557DOI: 10.1016/j.tetlet.2013.03.121ISI: 000318832200023OAI: oai:DiVA.org:umu-73557DiVA: diva2:632933
Available from: 2013-06-25 Created: 2013-06-25 Last updated: 2017-12-06Bibliographically approved

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