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Subgingival Biofilm Structure
Umeå University, Faculty of Medicine, Department of Odontology, Oral Microbiology.
Institute of Oral Biology, Section of Oral Microbiology and Immunology, University of Zürich, Zürich, Switzerland.
Institute of Oral Biology, Section of Oral Microbiology and Immunology, University of Zürich, Zürich, Switzerland.
Institute of Oral Biology, Section of Oral Microbiology and Immunology, University of Zürich, Zürich, Switzerland.
2012 (English)In: Periodontal Disease / [ed] Kinane D.F. (Philadelphia, Pa.), Mombelli A. (Geneva), S. Karger, 2012, 1-16 p.Chapter in book (Refereed)
Abstract [en]

Periodontitis is an inflammatory disease of the oral cavity initiated by a microbial biofilm (or 'dental plaque'). Subgingival biofilms in periodontal pockets are not easily analyzed without the loss of structural integrity. These subgingival plaques are structured communities of microorganisms with great phylogenetic diversity embedded in a self-produced extracellular polymeric matrix. For almost three decades, knowledge of the structure of plaque located below the gingival margin has been limited to landmark studies from the 1970s that were unaware of the breadth of microbial diversity we appreciate now. Only recently has technical progress - combining histology, confocal scanning fluorescent microscopy and fluorescent in situ hybridization to localize the most abundant species from different phyla and species associated with periodontitis - provided new insights into the architecture of subgingival biofilms. This review focuses on the structure and composition of subgingival biofilms and discusses current knowledge on the nature of the extracellular matrix. We describe further structural aspects of 'subgingival' biofilms produced in vitro that are gaining considerable interest as we search for models to investigate biofilm development, resistance to antibiotics, extracellular polymeric matrix composition and function, and reciprocal host-cell-to-biofilm interactions.

Place, publisher, year, edition, pages
S. Karger, 2012. 1-16 p.
Series
Frontiers of Oral Biology, ISSN 1420-2433 ; 15
National Category
Dentistry
Identifiers
URN: urn:nbn:se:umu:diva-74388DOI: 10.1159/000329667ISI: 000299437600002ISBN: 978-3-8055-9833-0 (print)ISBN: 978-3-8055-9834-7 (print)OAI: oai:DiVA.org:umu-74388DiVA: diva2:634092
Available from: 2013-06-28 Created: 2013-06-27 Last updated: 2013-06-28Bibliographically approved

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CiteExportLink to record
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