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Cytoplasmic pH Measurement and Homeostasis in Bacteria and Archaea
Department of Biology, Kenyon College.
Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, New York, NY USA.
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine.
2009 (English)In: Advances in Microbial Physiology, Vol 55 / [ed] Robert K. Poole, University of Sheffield, UK, Academic Press, 2009, 1-79 p.Chapter in book (Refereed)
Abstract [en]

Of all the molecular determinants for growth, the hydronium and hydroxide ions are found naturally in the widest concentration range, from acid mine drainage below pH 0 to soda lakes above pH 13. Most bacteria and archaea have mechanisms that maintain their internal, cytoplasmic pH within a narrower range than the pH outside the cell, termed "pH homeostasis." Some mechanisms of pH homeostasis are specific to particular species or groups of microorganisms while some common principles apply across the pH spectrum. The measurement of internal pH of microbes presents challenges, which are addressed by a range of techniques under varying growth conditions. This review compares and contrasts cytoplasmic pH homeostasis in acidophilic, neutralophilic, and alkaliphilic bacteria and archaea under conditions of growth, non-growth survival, and biofilms. We present diverse mechanisms of pH homeostasis including cell buffering, adaptations of membrane structure, active ion transport, and metabolic consumption of acids and bases.

Place, publisher, year, edition, pages
Academic Press, 2009. 1-79 p.
, Advances in Microbial Physiology, ISSN 0065-2911 ; 55
National Category
Microbiology in the medical area
URN: urn:nbn:se:umu:diva-75760DOI: 10.1016/S0065-2911(09)05501-5ISI: 000301674400001ISBN: 978-0-12-374790-7OAI: diva2:635328
Available from: 2013-07-03 Created: 2013-07-03 Last updated: 2016-02-25Bibliographically approved

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