Brain Tumors - Prognostic and Predictive Markers
2009 (English)In: Histological and Serological Tumor Markers and Gene Expression and Their Clinical Usefulness in Cancers / [ed] Dan Hellberg, Hauppauge: Nova Science Publishers, Inc., 2009, 53-75 p.Chapter in book (Refereed)
This review summarizes the status of prognostic and predictive markers in brain tumors with a focus on the most frequent tumors, gliomas. Brain tumors are a heterogeneous group of different tumors with a huge variation in outcome. Although the most common tumor, high-grade malignant glioma, still has a dismal prognosis, the last years have seen a significant improvement in the management in this tumor as well as in most other brain tumors. Age, tumor grade and KPS are still the most reliable prognostic and predictive variables available for patients with brain tumors. Although chromosome 1p/19q co-deletion and methylation status of the promoter of the MGMT gene (encoding O6-methylguanine-DNA methyl transferase) have been identified as the most promising potential predictors of response to chemotherapy in malignant gliomas, there are as yet no reliable biomarkers for tumour grading or tumour monitoring in the clinical setting.
Place, publisher, year, edition, pages
Hauppauge: Nova Science Publishers, Inc., 2009. 53-75 p.
Cancer and Oncology
IdentifiersURN: urn:nbn:se:umu:diva-76150ISI: 000275598500004ISBN: 978-1-60741-382-0OAI: oai:DiVA.org:umu-76150DiVA: diva2:635766