Styrketräningsadaption: Aminosyrafördelning och intracellulär signalering
Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Muscle mass regulation is responsive to a variety of stimuli, whereas amino acids and resistance exercise are two major regulators. Protein accretion occurs when the rate of protein synthesis exceeds the rate of protein degradation. It has long been recognized that both amino acid and resistance exercise effect protein synthesis and protein degradation, although the effect of varying distribution of amino acids remain unknown. The intracellular pathways by which protein synthesis are activated is complex. The purpose of this essay is to elucidate if there exist any scientific rationale to spread the amino acid intake over the day, with the purpose to maximize muscle protein accretion in response to resistance exercise. Furthermore , we intend to describe how amino acids and resistance exercise effect the molecular pathways that regulate protein synthesis, with the main focus on pathways that activate and are activated by mTOR.
Studies that examine acute effects on protein synthesis or protein balance after resistance exercise and amino acid intake support the notion that there may be an advantage to spread the amino acid intake over the day, since the synthetic response to amino acids are transient. However, studies examining the effect of different meal frequencies on protein accretion and /or training results fail to support this notion. Both amino acids and resistance exercise seems to independently activate the intracellular pathways that regulate protein synthesis, with the effect being greatest when both are combined. The regulation also seems to be dependent on exercise intensity and volume, age of test subjects, contraction type and muscle fiber type. Furthermore, some researchers have found correlations between activation of these pathways and resistance exercise-induced muscle gain and strength gain.
Place, publisher, year, edition, pages
2013. , 17 p.
Amino acids, Distribution, Muscle protein synthesis, Anabolic pathways, Resistance exercise
Sport and Fitness Sciences
IdentifiersURN: urn:nbn:se:umu:diva-76224OAI: oai:DiVA.org:umu-76224DiVA: diva2:636558
Sports Science Programme, Sports Medicine and Coaching
2013-06-03, Umeå, 09:00 (Swedish)
Isaksson, AndreasSvensson, Michael, Universitetslektor
Yu, Jiguo, Universitetslektor