2007 (English)In: Handbook on the Toxicology of Metals, 3rd edition / [ed] Gunnar F. Nordberg, Bruce A. Fowler, Monica Nordberg and Lars T. Friberg, San Diego: Elsevier, 2007, 3, 809-814 p.Chapter in book (Other academic)
Silver compounds may be absorbed through inhalation, but there are no quantitative human data on the extent of this phenomenon. Silver salts may be absorbed by up to 10-20% after ingestion. The highest concentrations of silver are usually found in the liver and spleen, and to some extent in the muscles, skin, and brain after ingestion. The biological half-time for silver ranges from a few days for animals up to approximately 50 days for the human liver; it is possible that skin deposits have an even longer half-time, but there are no quantitative data on this for man. Silver binds to high-molecular-weight proteins and metallothionein in tissue cytosol fractions. Excretion of silver from the body is primarily biliary. Water-soluble silver compounds such as the nitrate have a local corrosive effect and may cause fatal poisoning if swallowed accidentally. Chronic exposure of humans leads to argyria, a clinical entity characterized by grey-blue pigmentation of the skin and other body viscera. Repeated exposure of animals to silver may produce anemia, cardiac enlargement, growth retardation, and degenerative changes in the liver.
Place, publisher, year, edition, pages
San Diego: Elsevier, 2007, 3. 809-814 p.
Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:umu:diva-76463DOI: 10.1016/B978-012369413-3/50094-XISI: 000311285300041ISBN: 978-0-12-369413-3OAI: oai:DiVA.org:umu-76463DiVA: diva2:636765