umu.sePublikationer
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Non-steroidal anti-inflammatory drugs in colorectal surgery: a risk factor for anastomotic complications?
Umeå universitet, Medicinska fakulteten, Institutionen för kirurgisk och perioperativ vetenskap, Kirurgi.
Department of Molecular Medicine and Surgery, Karolinska Institutet, 17177 Stockholm, Sweden.
2012 (Engelska)Ingår i: World Journal of Gastrointestinal Surgery, ISSN 1948-9366, E-ISSN 1948-9366, Vol. 4, nr 12, s. 278-280Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

In a recent article, Gorissen et al report on 795 patients with primary colorectal anastomosis operated on during the period 2008-2010 for different colorectal conditions at two centres. The leakage rate was significantly higher among patients who were administered non-steroidal anti-inflammatory drugs (NSAIDs) in the perioperative course. A dose-response relationship could also be traced, where longer NSAID use yielded a higher risk of anastomotic breakdown. However, as this study is observational in design, confounding by indication may be present and there is also a risk of residual confounding from unmeasured covariates. Moreover, the question whether different affinity for the cyclooxygenase enzyme is important in different NSAIDs seems to be largely unanswered. The results, conclusions and clinical relevance of the aforementioned study, including the possible effects of different types of NSAIDs, are discussed. While acknowledging that this study represents the best attempt so far in establishing the causal relationship between perioperative NSAID use and anastomotic leakage, the need for further research in this important area is underlined.

Ort, förlag, år, upplaga, sidor
Baishideng Publishing Group Co., Limited , 2012. Vol. 4, nr 12, s. 278-280
Nyckelord [en]
Cancer, Colon, Non-steroidal anti-inflammatory drugs, Leakage, Rectum, Anastomotic leak
Nationell ämneskategori
Kirurgi
Identifikatorer
URN: urn:nbn:se:umu:diva-76749DOI: 10.4240/wjgs.v4.i12.278PubMedID: 23493636OAI: oai:DiVA.org:umu-76749DiVA, id: diva2:636836
Tillgänglig från: 2013-07-12 Skapad: 2013-07-12 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Rutegård, JörgenRutegård, Martin

Sök vidare i DiVA

Av författaren/redaktören
Rutegård, JörgenRutegård, Martin
Av organisationen
Kirurgi
I samma tidskrift
World Journal of Gastrointestinal Surgery
Kirurgi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 100 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf