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Surgical complications and long-term survival after esophagectomy for cancer in a nationwide Swedish cohort study
Upper Gastrointestinal Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
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2012 (English)In: European Journal of Surgical Oncology, ISSN 0748-7983, E-ISSN 1532-2157, Vol. 38, no 7, 555-561 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: Acute surgical complications after esophageal resection for cancer may decrease the long-term survival. Previous results on this topic are conflicting and no population-based studies are available.

METHODS: A prospective, nationwide Swedish study was conducted in 2001-2010. Eligible patients comprised those afflicted by esophageal or cardia cancer and underwent surgical resection in Sweden in 2001-2005. Details concerning patient and tumor characteristics, surgical procedures, and postoperative surgical complications were collected prospectively. Follow-up for mortality, starting from 90 days after the surgery, was done until May 2010. Cox proportional-hazards regression was performed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for age, tumor stage, sex, histology, comorbidity, surgical approach and surgical radicality.

RESULTS: Among 567 included patients who survived at least 90 days postoperatively, 130 (22.9%) sustained a predefined surgical complication within 30 days of surgery. The adjusted HR of mortality was increased in patients who sustained surgical complications, compared to patients without such complications (HR 1.29, 95% CI 1.02-1.63).

CONCLUSIONS: The occurrence of surgical complications might be an independent predictor for poorer long-term survival in patients resected for esophageal cancer, even in patients who survived the postoperative period.

Place, publisher, year, edition, pages
W.B. Saunders Co. Ltd. , 2012. Vol. 38, no 7, 555-561 p.
Keyword [en]
Esophagus, Population-based, Neoplasm, Surgery, Mortality, Leak
National Category
URN: urn:nbn:se:umu:diva-76755DOI: 10.1016/j.ejso.2012.02.177ISI: 000306040500001PubMedID: 22483704OAI: diva2:636839
Available from: 2013-07-12 Created: 2013-07-12 Last updated: 2015-08-24Bibliographically approved

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Rutegård, Martin
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