umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cellular and synaptic architecture of multisensory integration in the mouse neocortex
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
2013 (English)In: Neuron, ISSN 0896-6273, E-ISSN 1097-4199, Vol. 79, no 3, p. 579-593Article in journal (Refereed) Published
Abstract [en]

Multisensory integration (MI) is crucial for sensory processing, but it is unclear how MI is organized in cortical microcircuits. Whole-cell recordings in a mouse visuotactile area located between primary visual and somatosensory cortices revealed that spike responses were less bimodal than synaptic responses but displayed larger multisensory enhancement. MI was layer and cell type specific, with multisensory enhancement being rare in the major class of inhibitory interneurons and in the output infragranular layers. Optogenetic manipulation of parvalbumin-positive interneuron activity revealed that the scarce MI of interneurons enables MI in neighboring pyramids. Finally, single-cell resolution calcium imaging revealed a gradual merging of modalities: unisensory neurons had higher densities toward the borders of the primary cortices, but were located in unimodal clusters in the middle of the cortical area. These findings reveal the role of different neuronal subcircuits in the synaptic process of MI in the rodent parietal cortex.

Place, publisher, year, edition, pages
2013. Vol. 79, no 3, p. 579-593
National Category
Basic Medicine
Identifiers
URN: urn:nbn:se:umu:diva-79153DOI: 10.1016/j.neuron.2013.06.010PubMedID: 23850594OAI: oai:DiVA.org:umu-79153DiVA, id: diva2:641485
Available from: 2013-08-17 Created: 2013-08-09 Last updated: 2018-06-08Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records BETA

Medini, Paolo

Search in DiVA

By author/editor
Medini, Paolo
By organisation
Department of Molecular Biology (Faculty of Medicine)
In the same journal
Neuron
Basic Medicine

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 453 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf