Structural and functional recovery from early monocular deprivation in adult rats
2006 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 103, no 22, 8517-8522 p.Article in journal (Refereed) Published
Visual deficits caused by abnormal visual experience during development are hard to recover in adult animals. Removal of chondroitin sulfate proteoglycans from the mature extracellular matrix with chondroitinase ABC promotes plasticity in the adult visual cortex. We tested whether chondroitinase ABC treatment of adult rats facilitates anatomical, functional, and behavioral recovery from the effects of a period of monocular deprivation initiated during the critical period for monocular deprivation. We found that chondroitinase ABC treatment coupled with reverse lid-suturing causes a complete recovery of ocular dominance, visual acuity, and dendritic spine density in adult rats. Thus, manipulations of the extracellular matrix can be used to promote functional recovery in the adult cortex.
Place, publisher, year, edition, pages
2006. Vol. 103, no 22, 8517-8522 p.
IdentifiersURN: urn:nbn:se:umu:diva-79145DOI: 10.1073/pnas.0602657103PubMedID: 16709670OAI: oai:DiVA.org:umu-79145DiVA: diva2:641489