Change search
ReferencesLink to record
Permanent link

Direct link
Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
Show others and affiliations
2007 (English)In: Nature Neuroscience, ISSN 1097-6256, Vol. 10, no 6, 679-681 p.Article in journal (Refereed) Published
Abstract [en]

Loss of visual acuity caused by abnormal visual experience during development (amblyopia) is an untreatable pathology in adults. We report that environmental enrichment in adult amblyopic rats restored normal visual acuity and ocular dominance. These effects were due to reduced GABAergic inhibition in the visual cortex, accompanied by increased expression of BDNF and reduced density of extracellular-matrix perineuronal nets, and were prevented by enhancement of inhibition through benzodiazepine cortical infusion.

Place, publisher, year, edition, pages
2007. Vol. 10, no 6, 679-681 p.
National Category
Basic Medicine
URN: urn:nbn:se:umu:diva-79146DOI: 10.1038/nn1899PubMedID: 17468749OAI: diva2:641490
Available from: 2013-08-17 Created: 2013-08-09 Last updated: 2013-08-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Medini, Paolo
By organisation
Department of Molecular Biology (Faculty of Medicine)
In the same journal
Nature Neuroscience
Basic Medicine

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 59 hits
ReferencesLink to record
Permanent link

Direct link