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Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine).
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2007 (English)In: Nature Neuroscience, ISSN 1097-6256, E-ISSN 1546-1726, Vol. 10, no 6, 679-681 p.Article in journal (Refereed) Published
Abstract [en]

Loss of visual acuity caused by abnormal visual experience during development (amblyopia) is an untreatable pathology in adults. We report that environmental enrichment in adult amblyopic rats restored normal visual acuity and ocular dominance. These effects were due to reduced GABAergic inhibition in the visual cortex, accompanied by increased expression of BDNF and reduced density of extracellular-matrix perineuronal nets, and were prevented by enhancement of inhibition through benzodiazepine cortical infusion.

Place, publisher, year, edition, pages
2007. Vol. 10, no 6, 679-681 p.
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Basic Medicine
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URN: urn:nbn:se:umu:diva-79146DOI: 10.1038/nn1899PubMedID: 17468749OAI: oai:DiVA.org:umu-79146DiVA: diva2:641490
Available from: 2013-08-17 Created: 2013-08-09 Last updated: 2017-12-06Bibliographically approved

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Medini, Paolo

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