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Association between cannabinoid CB1 receptor expression and Akt signalling in prostate cancer
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
Umeå University, Faculty of Social Sciences, Umeå School of Business and Economics (USBE), Statistics.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Pharmacology.
2013 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, no 6, e65798- p.Article in journal (Refereed) Published
Abstract [en]

Background: In prostate cancer, tumour expression of cannabinoid CB1 receptors is associated with a poor prognosis. One explanation for this association comes from experiments with transfected astrocytoma cells, where a high CB receptor expression recruits the Akt signalling survival pathway. In the present study, we have investigated the association between CB1 receptor expression and the Akt pathway in a well-characterised prostate cancer tissue microarray.

Methodology/Principal Findings: Phosphorylated Akt immunoreactivity (pAkt-IR) scores were available in the database. CB1 receptor immunoreactivity (CB1IR) was rescored from previously published data using the same scale as pAkt-IR. There was a highly significant correlation between CB1IR and pAkt-IR. Further, cases with high expression levels of both biomarkers were much more likely to have a more severe form of the disease at diagnosis than those with low expression levels. The two biomarkers had additive effects, rather than an interaction, upon disease-specific survival.

Conclusions/Significance: The present study provides data that is consistent with the hypothesis that at a high CB1 receptor expression, the Akt signalling pathway becomes operative.

Place, publisher, year, edition, pages
2013. Vol. 8, no 6, e65798- p.
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:umu:diva-79271DOI: 10.1371/journal.pone.0065798ISI: 000320579400077OAI: oai:DiVA.org:umu-79271DiVA: diva2:645296
Available from: 2013-09-04 Created: 2013-08-13 Last updated: 2017-12-06Bibliographically approved

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Cipriano, MariateresaHäggström, JennyHammarsten, PeterFowler, Christopher J
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