Association between cannabinoid CB1 receptor expression and Akt signalling in prostate cancer
2013 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 8, no 6, e65798- p.Article in journal (Refereed) Published
Background: In prostate cancer, tumour expression of cannabinoid CB1 receptors is associated with a poor prognosis. One explanation for this association comes from experiments with transfected astrocytoma cells, where a high CB receptor expression recruits the Akt signalling survival pathway. In the present study, we have investigated the association between CB1 receptor expression and the Akt pathway in a well-characterised prostate cancer tissue microarray.
Methodology/Principal Findings: Phosphorylated Akt immunoreactivity (pAkt-IR) scores were available in the database. CB1 receptor immunoreactivity (CB1IR) was rescored from previously published data using the same scale as pAkt-IR. There was a highly significant correlation between CB1IR and pAkt-IR. Further, cases with high expression levels of both biomarkers were much more likely to have a more severe form of the disease at diagnosis than those with low expression levels. The two biomarkers had additive effects, rather than an interaction, upon disease-specific survival.
Conclusions/Significance: The present study provides data that is consistent with the hypothesis that at a high CB1 receptor expression, the Akt signalling pathway becomes operative.
Place, publisher, year, edition, pages
2013. Vol. 8, no 6, e65798- p.
Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:umu:diva-79271DOI: 10.1371/journal.pone.0065798ISI: 000320579400077OAI: oai:DiVA.org:umu-79271DiVA: diva2:645296