umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Coronary artery calcification correlates with the presence and severity of valve calcification
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology. Umeå Heart Centre.
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Cardiology. Umeå Heart Centre.
Show others and affiliations
2013 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 168, no 6, 5263-5266 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To investigate the prevalence of coronary artery calcification (CAC) in symptomatic individuals with CT evidence for left heart valve calcification, aortic valve (AVC), mitral valve (MAC) or both.

METHODS: This is a retrospective study of 282 consecutive patients with calcification in either the aortic valve or mitral annulus. Calcium scoring of the coronary artery, aortic and mitral valve was measured using the Agatston score.

RESULTS: AVC was more prevalent than MAC (64% vs. 2.5%, p<0.001), with 34% having both. Absence of CAC was noted in 12.7% of the study population. AVC+CAC were observed in 53.5%, MAC and CAC in 2.1%, and combined AVC, MAC and CAC in 31.6%. The median CAC score was higher in individuals with combined AVC+MAC, followed by those with AVC and lowest was in the MAC group. The majority (40%) of individuals with AVC had CAC score >400, and only in 16% had CAC=0. The same pattern was more evident in individuals with AVC+MAC, where 70% had CAC score >400 and only 6% had CAC score of 0. These results were irrespective of gender. There was no correlation between AVC and MAC but there was modest correlation between CAC score and AVC score (r=0.28, p=0.0001), MAC (r=0.36, p=0.0001) and with combined AVC+MAC (r=0.5, p=0.0001). AVC score of 262 had a sensitivity of 78% and specificity of 92% for the prediction of presence of CAC.

CONCLUSION: The presence and extent of calcification in the aortic valve or/and mitral valves are associated with severe coronary artery calcification.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 168, no 6, 5263-5266 p.
Keyword [en]
Coronary artery calcification, Valve calcification, Aortic valve calcification, Mitral annulus calcification
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:umu:diva-79926DOI: 10.1016/j.ijcard.2013.08.019PubMedID: 23993324OAI: oai:DiVA.org:umu-79926DiVA: diva2:645301
Available from: 2013-09-04 Created: 2013-09-04 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Investigation of the origin of the coronary artery calcification process and its relationship to the atherosclerotic cardiovascular disease
Open this publication in new window or tab >>Investigation of the origin of the coronary artery calcification process and its relationship to the atherosclerotic cardiovascular disease
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The objectives of this thesis are: a) To examine racial/ethnic differences in coronary artery calcification (CAC) and CAD, between symptomatic South Asians and Caucasians, matched for age, gender and conventional cardiovascular risk factors, b) To assess, using a meta-analysis model, the natural history of and stability of measurements of coronary artery calcium scoring (CACs) based on data collected from two large published trials: St Francis and EBEAT, c) To investigate the prevalence of coronary artery calcification in individuals with CT evidence for AVC, mitral valve calcification (MAC) or of both of them (AVC+MAC), d) To assess any potential association between premature CAD (<55 years in first-degree male relatives and <65 years in first-degree female relatives) and CAC in a large cohort of asymptomatic individuals.

We found that coronary artery calcification is more extensive and diffuse in symptomatic patients of South Asian ethnic origin as compared to Caucasians, despite similar conventional risk factors for CAD. This is more evident in those >50 years of age, suggesting potential genetic or other risk factors yet to be determined. The natural history of coronary artery calcification was overtime progression in the majority of subjects, irrespective of gender. The higher variability in RCA measurements could be related to the low baseline CACs or exaggerated movement of the right side atrioventricular ring, whereas those for LCA brances are influenced by the branch allocation of the CACs. Valve calcification is not isolated but involve also and the coronary arteries. The presence of calcification in the aortic valve or combined aortic and mitral valves predicted coronary artery calcification. Additionally patients in whom both valves have become calcified tend to have severe coronary artery calcification. And finally, there is no relationship between the prevalence and extent of coronary artery calcification and the presence of family history of coronary heart disease in asymptomatic individuals with none of the conventional risk factors for atherosclerosis.

Place, publisher, year, edition, pages
Umeå: Umeå universitet, 2013. 90 p.
Series
Umeå University medical dissertations, ISSN 0346-6612 ; 1619
Keyword
Coronary artery calcification, ethnicity, South Asians, Caucasians, reproducibility, aortic valve calcification, mitral valve calcification, family history of coronary artery disease, natural history, coronary artery calcium score, meta-analysis
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:umu:diva-83450 (URN)978-91-7459-774-5 (ISBN)
Public defence
2013-12-17, Sal D, unod T9, Norrlands universitetssjukhus, Umeå, 09:00 (English)
Opponent
Supervisors
Available from: 2013-11-26 Created: 2013-11-26 Last updated: 2013-11-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Koulaouzidis, GeorgeNicoll, RachelHenein, Michael Y

Search in DiVA

By author/editor
Koulaouzidis, GeorgeNicoll, RachelHenein, Michael Y
By organisation
Cardiology
In the same journal
International Journal of Cardiology
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 84 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf