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Indentation loading response of a resonance sensor: discriminating prostate cancer and normal tissue
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).
Umeå University, Faculty of Science and Technology, Department of Applied Physics and Electronics. Umeå University, Faculty of Science and Technology, Centre for Biomedical Engineering and Physics (CMTF).
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Urology and Andrology. (Njurcancer)ORCID iD: 0000-0002-4121-3753
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2013 (English)In: Journal of Medical Engineering & Technology, ISSN 0309-1902, E-ISSN 1464-522X, Vol. 37, no 7, 416-423 p.Article in journal (Refereed) Published
Abstract [en]

Prostate cancer is the most common type of cancer among men worldwide. Mechanical properties of prostate tissue are promising for distinguishing prostate cancer from healthy prostate tissue. The aim was to investigate the indentation loading response of a resonance sensor for discriminating prostate cancer tissue from normal tissue. Indentation measurements were done on prostate tissue specimens ex vivo from 10 patients from radical prostatectomy. The measurement areas were analysed using standard histological methods. The stiffness parameter was linearly dependent on the loading force (average R2 = 0.90) and an increased loading force caused a greater stiffness contrast of prostate cancer vs normal tissue. The accuracy of the stiffness contrast was assessed by the ROC curve with the area under the curve being 0.941 for a loading force of 12.8 mN. The results are promising for the development of a resonance sensor instrument for detecting prostate cancer.

Place, publisher, year, edition, pages
Taylor & Francis, 2013. Vol. 37, no 7, 416-423 p.
Keyword [en]
Indentation, loading, prostate cancer, resonance sensor, stiffness
National Category
Medical Engineering Medical Laboratory and Measurements Technologies
Identifiers
URN: urn:nbn:se:umu:diva-79947DOI: 10.3109/03091902.2013.824510OAI: oai:DiVA.org:umu-79947DiVA: diva2:645347
Available from: 2013-09-04 Created: 2013-09-04 Last updated: 2017-12-06Bibliographically approved

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Jalkanen, VilleAndersson, BrittBergh, AndersLjungberg, BörjeLindahl, Olof

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Jalkanen, VilleAndersson, BrittBergh, AndersLjungberg, BörjeLindahl, Olof
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Journal of Medical Engineering & Technology
Medical EngineeringMedical Laboratory and Measurements Technologies

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