Increase in skin autofluorescence and release of heart-type fatty acid binding protein in plasma predicts mortality of hemodialysis patients
2013 (English)In: Artificial Organs, ISSN 0160-564X, E-ISSN 1525-1594, Vol. 37, no 7, E114-E122 p.Article in journal (Refereed) Published
Advanced glycation end-products (AGEs) are uremic toxins that accumulate progressively in hemodialysis (HD) patients. The aim of this study was to assess the 1-year increase in skin autofluorescence (DAF), a measure of AGEs accumulation and plasma markers, as predictors of mortality in HD patients. One hundred sixty-nine HD patients were enrolled in this study. Skin autofluorescence was measured twice, 1 year apart using an AGE Reader (DiagnOptics Technologies BV, Groningen, The Netherlands). Besides routine blood chemistry, additional plasma markers including superoxide dismutase, myeloperoxydase, intercellular adhesion molecule 1 (ICAM-1), C-reactive protein (hs-CRP), heart-type fatty acid binding protein (H-FABP), and von Willebrand factor were measured at baseline. The mortality of HD patients was followed for 36 months. Skin autofluorescence values of the HD patients at the two time points were significantly higher (P < 0.001) than those of healthy subjects of the same age. Mean 1-year DAF of HD patients was 0.16 +/- 0.06, which was around seven-to ninefold higher than 1-year DAF in healthy subjects. Multivariate Cox regression showed that age, hypertension, 1-year DAF, hs-CRP, ICAM-1, and H-FABP were independent predictors of overall mortality. Hypertension, 1-year DAF, hs-CRP, and H-FABP were also independent predictors of cardiovascular mortality. One-year DAF and plasma H-FABP, used separately and in combination, are strong predictors of overall and cardiovascular mortality in HD patients.
Place, publisher, year, edition, pages
2013. Vol. 37, no 7, E114-E122 p.
Advanced glycation end-products, Cardiovascular disease, Heart-type fatty acid binding protein, Hemodialysis, Mortality, Skin autofluorescence
Biomedical Laboratory Science/Technology
IdentifiersURN: urn:nbn:se:umu:diva-79254DOI: 10.1111/aor.12078ISI: 000321442400006OAI: oai:DiVA.org:umu-79254DiVA: diva2:645727