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Smoking status, snus use, and variation at the CHRNA5-CHRNA3-CHRNB4 locus in relation to obesity: the GLACIER study
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Nutritional Research. Umeå University, Faculty of Medicine, Department of Biobank Research.ORCID iD: 0000-0001-9581-3845
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2013 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 178, no 1, 31-37 p.Article in journal (Refereed) Published
Abstract [en]

A genetic variant within the CHRNA5-CHRNA3-CHRNB4 region (rs1051730), previously associated with smoking quantity, was recently shown to interact with smoking on obesity predisposition. We attempted to replicate this finding in the Gene-Lifestyle Interactions and Complex Traits Involved in Elevated Disease Risk (GLACIER) Study, a prospective cohort study of adults from northern Sweden (n = 16,426). We also investigated whether a similar interaction is apparent between rs1051730 and snus, a type of moist oral tobacco, to determine whether this interaction is driven by factors that cigarettes and snus have in common, such as nicotine. Main effects of smoking, snus, and the rs1051730 variant and pairwise interaction terms (smoking x rs1051730 and snus x rs1051730) were tested in relation to body mass index (BMI; calculated as weight (kg)/height (m)(2)) through the use of multivariate linear models adjusted for age and sex. Smoking status and BMI were inversely related (beta = -0.46 kg/m(2), standard error (SE) = 0.08; P < 0.0001). Snus use and BMI were positively related (beta = 0.35 kg/m(2), SE = 0.12; P = 0.003). The rs1051730 variant was not significantly associated with smoking status or snus use (P > 0.05); the T allele was associated with lower BMI in the overall cohort (beta = -0.10 kg/m(2), SE = 0.05; P = 0.03) and with smoking quantity in those in whom this was measured (n = 5,304) (beta = 0.08, SE = 0.01; P < 0.0001). Neither smoking status (P-interaction = 0.29) nor snus use (P-interaction = 0.89) modified the association between the rs1051730 variant and BMI.

Place, publisher, year, edition, pages
2013. Vol. 178, no 1, 31-37 p.
Keyword [en]
body mass index, gene-environment interaction, genetic association studies, polymorphism, single nucleotide, smoking, tobacco, smokeless
National Category
Public Health, Global Health, Social Medicine and Epidemiology Environmental Health and Occupational Health
URN: urn:nbn:se:umu:diva-79253DOI: 10.1093/aje/kws413ISI: 000321449400004OAI: diva2:645730
Available from: 2013-09-05 Created: 2013-08-13 Last updated: 2015-04-22Bibliographically approved

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Hallmans, GöranFranks, Paul W
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Nutritional ResearchDepartment of Biobank ResearchMedicine
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Public Health, Global Health, Social Medicine and EpidemiologyEnvironmental Health and Occupational Health

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