Differences in Clinical Profile of Individuals With Severe and Markedly Elevated Coronary Artery Calcification Detected by Electron Beam Computed Tomography
2013 (English)In: Angiology, ISSN 0003-3197, E-ISSN 1940-1574, Vol. 64, no 6, 435-439 p.Article in journal (Refereed) Published
Although several studies have demonstrated the association between coronary artery calcification (CAC) and coronary artery disease events, the underlying mechanism has not been fully elucidated. Furthermore, extensive CAC still remains a poorly understood phenomenon. The objective of this study is to determine the clinical characteristics and differences between 831 asymptomatic individuals with very high CAC scores (CACS 1000) and 497 asymptomatic individuals with CAC scores of 400 to 999. Individuals with CACS 1000 were more likely to have hypertension ([HTN]; P = .0004), hypercholesterolemia (P = .0001), diabetes mellitus ([DM] P = .005), and high body mass index ([BMI]; P = .03) compared with individuals with CACS = 400-999. On multivariable analysis, age (P < .0001) and BMI (P = .01) were found to be significant risk factors for the presence of very high CAC. While for males, age (P < .0001), hypercholesterolemia (P = .001), DM (P = .002), and obesity (P = .003) were independent risk factors; in females only HTN (P = .04) was independent risk factor.
Place, publisher, year, edition, pages
2013. Vol. 64, no 6, 435-439 p.
coronary artery calcification, coronary artery calcium score, electron beam computed tomography
Cardiac and Cardiovascular Systems
IdentifiersURN: urn:nbn:se:umu:diva-79887DOI: 10.1177/0003319712454217ISI: 000322647800007OAI: oai:DiVA.org:umu-79887DiVA: diva2:645985