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Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). (Hallberg)
Umeå University, Faculty of Science and Technology, Department of Molecular Biology (Faculty of Science and Technology). (Palmer)
2013 (English)In: Nature Reviews. Cancer, ISSN 1474-175X, E-ISSN 1474-1768, ISSN 1474-1768, Vol. 13, no 10, 685-700 p.Article in journal (Refereed) Published
Abstract [en]

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer (NSCLC). The common activation of ALK has led to the use of the ALK tyrosine kinase inhibitor (TKI) crizotinib in a range of patient populations and to the rapid development of second-generation drugs targeting ALK. In this Review, we discuss our current understanding of ALK function in human cancer and the implications for tumour treatment.

Place, publisher, year, edition, pages
Nature Publishing Group, 2013. Vol. 13, no 10, 685-700 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:umu:diva-81089DOI: 10.1038/nrc3580ISI: 000324866100008PubMedID: 24060861OAI: oai:DiVA.org:umu-81089DiVA: diva2:652988
Funder
Swedish Cancer Society, 12-0722, 12-0796Swedish Research Council, 621-2011-5181, 521-2012-2831
Available from: 2013-10-02 Created: 2013-10-02 Last updated: 2017-12-06Bibliographically approved

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Hallberg, BengtPalmer, Ruth H

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