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Modes of cell wall growth differentiation in rod-shaped bacteria
Umeå University, Faculty of Medicine, Department of Molecular Biology (Faculty of Medicine). Umeå University, Faculty of Medicine, Umeå Centre for Microbial Research (UCMR). Umeå University, Faculty of Medicine, Molecular Infection Medicine Sweden (MIMS).
2013 (English)In: Current Opinion in Microbiology, ISSN 1369-5274, E-ISSN 1879-0364, Vol. 16, no 6, 731-737 p.Article in journal (Refereed) Published
Abstract [en]

A bacterial cell takes on the challenge to preserve and reproduce its shape at every generation against a substantial internal pressure by surrounding itself with a mechanical support, a peptidoglycan cell wall. The enlargement of the cell wall via net incorporation of precursors into the pre-existing wall conditions bacterial growth and morphology. However, generation, reproduction and/or modification of a specific shape requires that the incorporation takes place at precise locations for a defined time period. Much has been learnt in the past few years about the biochemistry of the peptidoglycan synthesis process, but topological approaches to the understanding of shape generation have been hindered by a lack of appropriate techniques. Recent technological advances are paving the way for substantial progress in understanding the mechanisms of bacterial morphogenesis. Here we review the latest developments, focusing on the impact of new techniques on the precise mapping of cell wall growth sites.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 16, no 6, 731-737 p.
National Category
Microbiology in the medical area Cell and Molecular Biology Infectious Medicine
URN: urn:nbn:se:umu:diva-81854DOI: 10.1016/j.mib.2013.09.004PubMedID: 24094807OAI: diva2:658601
NIH (National Institute of Health), GM51986Knut and Alice Wallenberg Foundation
Available from: 2013-10-22 Created: 2013-10-22 Last updated: 2014-02-05Bibliographically approved

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Cava, Felipe
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Department of Molecular Biology (Faculty of Medicine)Umeå Centre for Microbial Research (UCMR)Molecular Infection Medicine Sweden (MIMS)
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Current Opinion in Microbiology
Microbiology in the medical areaCell and Molecular BiologyInfectious Medicine

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