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D-amino acids govern stationary phase cell wall remodeling in bacteria
Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.
Channing Laboratory, Brigham and Women’s Hospital, Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA, USA.
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2009 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 325, no 5947, 1552-1555 p.Article in journal (Refereed) Published
Abstract [en]

In all known organisms, amino acids are predominantly thought to be synthesized and used as their L-enantiomers. Here, we found that bacteria produce diverse D-amino acids as well, which accumulate at millimolar concentrations in supernatants of stationary phase cultures. In Vibrio cholerae, a dedicated racemase produced D-Met and D-Leu, whereas Bacillus subtilis generated D-Tyr and D-Phe. These unusual D-amino acids appear to modulate synthesis of peptidoglycan, a strong and elastic polymer that serves as the stress-bearing component of the bacterial cell wall. D-Amino acids influenced peptidoglycan composition, amount, and strength, both by means of their incorporation into the polymer and by regulating enzymes that synthesize and modify it. Thus, synthesis of D-amino acids may be a common strategy for bacteria to adapt to changing environmental conditions.

Place, publisher, year, edition, pages
2009. Vol. 325, no 5947, 1552-1555 p.
National Category
Biochemistry and Molecular Biology
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URN: urn:nbn:se:umu:diva-81862DOI: 10.1126/science.1178123PubMedID: 19762646Archive number: 000269887900043OAI: oai:DiVA.org:umu-81862DiVA: diva2:658610
Available from: 2013-10-22 Created: 2013-10-22 Last updated: 2017-12-06Bibliographically approved

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Cava, Felipe

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