umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Mitochondrial translation initiation machinery: conservation and diversification
University of Tartu, Institute of Technology ; Molecular Biology Department, Faculty of Biology, M.V. Lomonosov Moscow State University.
University of Tartu, Institute of Technology.
Molecular Biology Department, Faculty of Biology, M.V. Lomonosov Moscow State University.
Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, United Kingdom.
Show others and affiliations
2014 (English)In: Biochimie, ISSN 0300-9084, E-ISSN 1638-6183, Vol. 100C, 132-140 p.Article in journal (Refereed) Published
Abstract [en]

The highly streamlined mitochondrial genome encodes almost exclusively a handful of transmembrane components of the respiratory chain complex. In order to ensure the correct assembly of the respiratory chain, the products of these genes must be produced in the correct stoichiometry and inserted into the membrane, posing a unique challenge to the mitochondrial translational system. In this review we describe the proteins orchestrating mitochondrial translation initiation: bacterial-like general initiation factors mIF2 and mIF3, as well as mitochondria-specific components - mRNA-specific translational activators and mRNA-nonspecific accessory initiation factors. We consider how the fast rate of evolution in these organelles has not only created a system that is divergent from that of its bacterial ancestors, but has led to a huge diversity in lineage specific mechanistic features of mitochondrial translation initiation among eukaryotes.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 100C, 132-140 p.
Keyword [en]
Mitochondria, Ribosome, IF2, IF3, Translational activators
National Category
Biochemistry and Molecular Biology Evolutionary Biology
Identifiers
URN: urn:nbn:se:umu:diva-81892DOI: 10.1016/j.biochi.2013.07.024ISI: 000335101400014PubMedID: 23954798OAI: oai:DiVA.org:umu-81892DiVA: diva2:658699
Available from: 2013-10-22 Created: 2013-10-22 Last updated: 2017-12-06Bibliographically approved

Open Access in DiVA

fulltext(2261 kB)147 downloads
File information
File name FULLTEXT03.pdfFile size 2261 kBChecksum SHA-512
33efa8988f05ff5f15020962034a04614b2e090f7c2eb40cda3ace85269fcf5ceb84f51c10b0eaf0f78ae2d018690d79d4f059dfe1820fadf3a8391c1c08a966
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedhttp://www.sciencedirect.com/science/article/pii/S0300908413002472#

Authority records BETA

Hauryliuk, Vasili

Search in DiVA

By author/editor
Hauryliuk, Vasili
By organisation
Molecular Infection Medicine Sweden (MIMS)Department of Molecular Biology (Faculty of Medicine)
In the same journal
Biochimie
Biochemistry and Molecular BiologyEvolutionary Biology

Search outside of DiVA

GoogleGoogle Scholar
Total: 151 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 171 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf