Staphylokinase Promotes the Establishment of Staphylococcus aureus Skin Infections While Decreasing Disease Severity
2013 (English)In: Journal of Infectious Diseases, ISSN 0022-1899, Vol. 208, no 6, 990-999 p.Article in journal (Refereed) Published
Skin infections are frequently caused by Staphylococcus aureus and can lead to a fatal sepsis. The microbial mechanisms controlling the initiation and progression from mild skin infection to a severe disseminated infection remain poorly understood. Using a combination of clinical data and in vitro and ex vivo assays, we show that staphylokinase, secreted by S. aureus, promoted the establishment of skin infections in humans and increased bacterial penetration through skin barriers by activating plasminogen. However, when infection was established, the interaction between staphylokinase and plasminogen did not promote systemic dissemination but induced the opening and draining of abscesses and decreased disease severity in neutropenic mice. Also, increased staphylokinase production was associated with noninvasive S. aureus infections in patients. Our results point out the dual roles of staphylokinase in S. aureus skin infections as promoting the establishment of infections while decreasing disease severity.
Place, publisher, year, edition, pages
Oxford University Press, 2013. Vol. 208, no 6, 990-999 p.
staphylococcus, staphylokinase, plasminogen, skin infection, mouse model, pathogen-host relation
Immunology in the medical area Microbiology in the medical area Infectious Medicine
IdentifiersURN: urn:nbn:se:umu:diva-81832DOI: 10.1093/infdis/jit288ISI: 000324510200015OAI: oai:DiVA.org:umu-81832DiVA: diva2:659221