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Subcutaneous implanted chambers in different mouse strains as an animal model to study genetic stability during infection with Lyme disease Borrelia
Umeå University, Faculty of Medicine, Microbiology.ORCID iD: 0000-0001-7175-1336
Umeå University, Faculty of Medicine, Microbiology.
Umeå University, Faculty of Medicine, Microbiology.
1995 (English)In: Microbial Pathogenesis, ISSN 0882-4010, E-ISSN 1096-1208, Vol. 18, no 2, 109-14 p.Article in journal (Refereed) Published
Abstract [en]

Tissue metal net cages were implanted subcutaneously in BALB/cJ and C3H/Tif mice as an experimental model of Borrelia burgdorferi infection. B. burgdorferi sensu stricto strain Sh2-82 could be isolated up to 14 weeks after the inoculation. However, a significant difference in infectivity between the two mice strains was observed. C3H/Tif mice were more susceptible to developing chronic B. burgdorferi s.s. infections than BALB/cJ mice. Although a B. burgdorferi infection was established, no rearrangements in the ospA and ospB genes were observed in any of the infected mice.

Place, publisher, year, edition, pages
Academic Press, 1995. Vol. 18, no 2, 109-14 p.
Keyword [en]
Borrelia burgdorferi, ospAB operon, genetic stability, subcutaneous chambers
National Category
Immunology in the medical area Microbiology in the medical area
URN: urn:nbn:se:umu:diva-82023DOI: 10.1016/S0882-4010(95)90101-9PubMedID: 7543971OAI: diva2:659382
Available from: 2013-10-25 Created: 2013-10-25 Last updated: 2016-08-22Bibliographically approved

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