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Tumor indicating normal tissue could be a new source of diagnostic and prognostic markers for prostate cancer
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
Umeå University, Faculty of Medicine, Department of Medical Biosciences, Pathology.
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2011 (English)In: Expert Opinion in Medical Diagnostics, ISSN 1753-0059, E-ISSN 1753-0067, Vol. 5, no 1, 37-47 p.Article in journal (Refereed) Published
Abstract [en]

Importance of the field: Prostate cancer is a common and multifocal disease but the diagnostic methods available are unsatisfactory. Most tumors present are of low malignant potential, whereas others are highly aggressive. At present, imaging cannot be used to guide tissue biopsies safely towards the most aggressive tumor present. To handle this problem multiple needle biopsies are taken. The biopsies often contain only normal prostate tissue, and even if the tumor is sampled it is not known whether a more aggressive cancer is present elsewhere in the organ. If changes in the normal tissue indicate the presence and nature of tumors, this information could be used to improve diagnostics and prognostics of prostate cancer. Areas covered in this review: Current evidence that the tumor-adjacent morphologically normal prostate tissue is not completely normal is reviewed, and that this tissue, named tumor indicating normal tissue (TINT) by the authors, can be used to diagnose prostate cancer. What the reader will gain: The reader will understand that tumors need to affect their surroundings in order to grow and metastasize and that the normal prostate tissue is therefore tinted by the presence and nature of cancer and that this knowledge can be used to develop new diagnostic and prognostic markers. Take home message: TINT changes could probably, when more rigorously defined and validated, be used to diagnose and prognosticate prostate cancer.

Place, publisher, year, edition, pages
Informa Healthcare, 2011. Vol. 5, no 1, 37-47 p.
Keyword [en]
cancer field effect, diagnostic marker, prognostic marker, prostate biopsy, prostate cancer, tumor indicating normal tissue, tumor stroma
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:umu:diva-82046DOI: 10.1517/17530059.2011.540009PubMedID: 23484475OAI: oai:DiVA.org:umu-82046DiVA: diva2:659517
Available from: 2013-10-25 Created: 2013-10-25 Last updated: 2017-12-06Bibliographically approved

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Halin Bergström, SofiaHammarsten, PeterAdamo, HaniWikström, PernillaBergh, Anders
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