Synthesis of fluorescent ring-fused 2-pyridone peptidomimetics
2013 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 78, no 23, 12207-12213 p.Article in journal (Refereed) Published
Thiazolino fused 2-pyridones peptidomimetics are of significant biological importance due to their ability to interfere with adhesive fiber formation in uropathogenic Escherichia coli and oligomerization of amyloid fibres. We have developed an efficient synthetic route to fluorescent BODIPY analogues, with structural diversification from a key intermediate enabling introduction of C-2 substituents and late incorporation of the BODIPY moiety. A mild lithium halide mediated hydrolysis enabled preparation of peptidomimetic fluorophores with useful photophysical properties for further chemical biology applications.
Place, publisher, year, edition, pages
American Chemical Society (ACS), 2013. Vol. 78, no 23, 12207-12213 p.
IdentifiersURN: urn:nbn:se:umu:diva-82342DOI: 10.1021/jo401844yPubMedID: 24161000OAI: oai:DiVA.org:umu-82342DiVA: diva2:660714
FunderSwedish Research Council, 621-2010-4730