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Comparative association analysis reveals that corneodesmosin is more closely associated with psoriasis than HLA-Cw*0602-B*5701 in German families
Department of Dermatology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.ORCID-id: 0000-0002-3858-8474
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2001 (Engelska)Ingår i: Tissue Antigens, ISSN 0001-2815, E-ISSN 1399-0039, Vol. 57, nr 5, s. 440-446Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

HLA antigens are associated with psoriasis vulgaris across populations with different ethnic background. We have previously shown that in Caucasians this association is primarily based on the class I alleles of the extended HLA haplotype 57.1 (EH57.1/I), HLA-Cw6-HLA-B57. However, it remained unclear whether HLA-Cw6 itself or a closely linked locus predisposes to the disease. An interesting candidate for this presumed locus is corneodesmosin, which is exclusively synthesized in keratinocytes. The corneodesmosin gene locus (CDSN) is only 160 kb telomeric to HLA-C and tightly associated with psoriasis. In order to find out whether EH57.1/I or a corneodesmosin variant are the susceptibility determinants on 6p, HLA class I alleles and single-nucleotide polymorphisms (SNPs) of corneodesmosin were investigated at the sequence level and analyzed by comparative association tests. Transmission disequilibrium tests (TDT) were performed in 52 nuclear families, of which 36 were fully informative for a joint comparison of HLA and CDSN with regard to association to psoriasis. The extended TDT according to Wilson was employed to test for locus interaction. Using the HLA haplotype EH57.1/I and the CDSN haplotype formed by three intragenic variant sites at nt=619 (T), 1236 (T), and 1243 (C), we obtained the best resolution of parental transmission to index cases in the trio families. On direct comparison of the contributions of the HLA and the CDSN haplotypes, there was a markedly stronger association of the corneodesmosin TTC haplotype, which is not apparent in single locus analysis. We show furthermore that there is no higher order interaction between psoriasis, HLA, and CDSN. This lack of three-locus interaction is suggestive of two independent genetic contributions to psoriasis within the major histocompatibility complex (MHC).

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John Wiley & Sons, 2001. Vol. 57, nr 5, s. 440-446
Nyckelord [en]
hereditary diseases;genetics;disease-susceptibility;histocompatibility antigens;autoimmune disease;genetic markers
Nationell ämneskategori
Dermatologi och venereologi
Identifikatorer
URN: urn:nbn:se:umu:diva-82444DOI: 10.1034/j.1399-0039.2001.057005440.xISI: 000169685400005PubMedID: 11556968OAI: oai:DiVA.org:umu-82444DiVA, id: diva2:661162
Tillgänglig från: 2013-11-01 Skapad: 2013-11-01 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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