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Familial juvenile onset psoriasis is associated with the human leukocyte antigen (HLA) class I side of the extended haplotype Cw6-B57-DRB1*0701-DQA1*0201-DQB1*0303: a population- and family-based study
Department of Dermatology, School of Medicine (Charité), Humboldt University, Berlin, Germany & Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, University of Vienna Medical School, Vienna, Austria.ORCID iD: 0000-0002-3858-8474
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1996 (English)In: Journal of Investigative Dermatology, ISSN 0022-202X, E-ISSN 1523-1747, Vol. 106, no 4, 711-714 p.Article in journal (Refereed) Published
Abstract [en]

To further evaluate the nature of the HLA association with psoriasis, HLA haplotypes of 60 patients with type 1 (early onset, positive family history) and 30 patients with type II (late onset, no family history) psoriasis were investigated by polymerase chain reaction sequence-specific oligonucleotide hybridization (HLA class II) and serology (HLA class I). Ethnically matched blood donors (146) served as controls. In type I, but not type II psoriasis, the Caucasian HLA extended haplotype (EH) Cw6-B57-DRB1*0701-DQA1*0201-DQB1*0303 named according to the B allele EH-57.1 was highly significantly overrepresented (p cor= 0.00021). This particular EH was present in 35% of type I psoriatics but only 2% of controls. EH-57.1+ individuals therefore carry a 26 times higher risk of developing type I psoriasis than individuals who are EH-57.1-negative Further analysis of individual HLA alleles revealed that within EH-57.1, HLA class I antigens (Cw6-B57) were associated to a much higher extent with type I psoriasis than the HLA class II alleles (DRB1*0701-DQA1*0201-DQB1* 0303). Pedigree analysis of three multiply affected families over three generations revealed a cosegregation of disease with EH-57.1. These results strongly suggest that a gene for familial psoriasis is associated with the class I side of the extended haplotype Cw6-B57-DRB1*0701-DQA1*0201-DQB1*0303.

Place, publisher, year, edition, pages
Nature Publishing Group, 1996. Vol. 106, no 4, 711-714 p.
Keyword [en]
histocompatibility antigens; disease susceptibility; polymerase chain reaction; autoimmune disease; major histocompatibility complex; ancestral haplotypes; mhc; vulgaris; region; genes
National Category
Dermatology and Venereal Diseases
URN: urn:nbn:se:umu:diva-82429DOI: 10.1111/1523-1747.ep12345600ISI: A1996UC78700021PubMedID: 8618009OAI: diva2:661168
Available from: 2013-11-01 Created: 2013-11-01 Last updated: 2014-06-30Bibliographically approved

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Schmitt-Egenolf, Marcus
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