Change search
ReferencesLink to record
Permanent link

Direct link
PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis.
Department of Dermatology, School of Medicine, Humboldt University, Berlin, Germany.ORCID iD: 0000-0002-3858-8474
Show others and affiliations
2000 (English)In: Clinical and Experimental Immunology, ISSN 0009-9104, E-ISSN 1365-2249, Vol. 119, no 3, 553-558 p.Article in journal (Refereed) Published
Abstract [en]

The susceptibility genes for psoriasis remain to be identified. At least one of these must be in the major histocompatibility complex (MHC) to explain associations with alleles at human leucocyte antigen (HLA)-A, -B, -C, -DR, -DQ and C4. In fact, most of these alleles are components of just two ancestral haplotypes (AHs) designated 13.1 and 57.1. Although relevant MHC gene(s) could be within a region of at least 4 Mb, most studies have favoured the area near HLA-B and -C. This region contains a large number of non-HLA genes, many of which are duplicated and polymorphic. Members of one such gene family, PERB11.1 and PERB11.2, are expressed in the skin and are encoded in the region between tumour necrosis factor and HLA-B. To investigate the relationship of PERB11.1 alleles to psoriasis, sequence based typing was performed on 97 patients classified according to age of onset and family history. The frequency of the PERB11.1*06 allele is 44% in type I psoriasis but only 7% in controls (Pc = 0.003 by Fisher's exact test, two-tailed). The major determinant of this association is a single nucleotide polymorphism (SNP) within intron 4. In normal and affected skin, expression of PERB11 is mainly in the basal layer of the epidermis including ducts and follicles. PERB11 is also present in the upper keratin layers but there is relative deficiency in the intermediate layers. These findings suggest a possible role for PERB11 and other MHC genes in the pathogenesis of psoriasis.

Place, publisher, year, edition, pages
John Wiley & Sons, 2000. Vol. 119, no 3, 553-558 p.
Keyword [en]
psoriasis;major histocompatibility complex;ancestral haplotypes;PERB11 (MIC)
National Category
Dermatology and Venereal Diseases
URN: urn:nbn:se:umu:diva-82431DOI: 10.1046/j.1365-2249.2000.01140.xISI: 000085503700024PubMedID: 10691930OAI: diva2:661172
Available from: 2013-11-01 Created: 2013-11-01 Last updated: 2014-06-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Schmitt-Egenolf, Marcus
In the same journal
Clinical and Experimental Immunology
Dermatology and Venereal Diseases

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 13 hits
ReferencesLink to record
Permanent link

Direct link