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Analysis of TAP2 and HLA-DP gene polymorphism in psoriasis
Department of Dermatology, University of Ulm, Ulm, Germany.ORCID iD: 0000-0002-3858-8474
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1994 (English)In: Human Immunology, ISSN 0198-8859, E-ISSN 1879-1166, Vol. 40, no 4, 299-302 p.Article in journal (Refereed) Published
Abstract [en]

TAP2 is a gene, located between HLA-DP and HLA-DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in this gene. TAP2 is of particular interest because its involvement in antigen presentation makes it a candidate for a disease susceptibility gene. In psoriasis, two clinical subtypes analogous to the situation in diabetes type I with early onset and family history and type II with later onset and without family history have been described. We have previously shown that type I but not type II psoriasis is associated with the HLA-DRB1*0701/2, -DQA1*0201, -DQB1*0303 haplotype. To investigate whether this haplotype extends to include particular TAP2 and/or DP alleles, we tested the TAP2 and HLA-DP alleles of a control group (n = 199), patients with psoriasis type I (n = 66), and patients with psoriasis type II (n = 35) by hybridization with SSOs. Our data show that there is no significant correlation between TAP2 and/or HLA-DP gene polymorphism and psoriasis type I and/or type II. We conclude that disease association in type I psoriasis is associated with the extended haplotype HLA-B57, -Cw6, -DRB1*0701/2, -DQA1*0201, -DQB1*0303.

Place, publisher, year, edition, pages
1994. Vol. 40, no 4, 299-302 p.
Keyword [en]
mhc class-ii; major histocompatibility complex; oligonucleotide probes; langerhans cells; antigen; transporter; molecules; dna; expression; autoimmunity
National Category
Dermatology and Venereal Diseases
URN: urn:nbn:se:umu:diva-82432DOI: 10.1016/0198-8859(94)90029-9ISI: A1994PG06500006PubMedID: 8002377OAI: diva2:661174
Available from: 2013-11-01 Created: 2013-11-01 Last updated: 2014-06-30Bibliographically approved

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Schmitt-Egenolf, Marcus
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