Genomewide scan in german families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13
2000 (English)In: American Journal of Human Genetics, ISSN 0002-9297, E-ISSN 1537-6605, Vol. 67, no 4, 1020-1024 p.Article in journal (Refereed) Published
Psoriasis is a common chronic inflammatory skin disease with a strong genetic component. Few psoriasis-susceptibility loci have been reported, and only two have been confirmed in independent data sets. This article reports results of a genomewide scan that was performed, using 370 microsatellite markers, for psoriasis-susceptibility loci in 32 German extended families, comprising 162 affected and 195 unaffected individuals. Nonparametric linkage analysis of all families provided strong evidence for a novel psoriasis-susceptibility locus on chromosome 19p (Zlr=3.50; P=.0002). Parametric analysis revealed a heterogeneity LOD score of 4.06, corresponding to a genomewide significance level of.037, under the assumption of a recessive model with high disease-allele frequency and 66% as the proportion of linked families. This study confirms linkage of psoriasis to the HLA region on chromosome 6p and suggests additional regions on chromosomes 8q and 21q for further investigations.
Place, publisher, year, edition, pages
Elsevier, 2000. Vol. 67, no 4, 1020-1024 p.
linkage analysis; genetic dissection; complex traits; disease; identification; simulation; activation; models; map; hla
Dermatology and Venereal Diseases
IdentifiersURN: urn:nbn:se:umu:diva-82442DOI: 10.1086/303075PubMedID: 10986047OAI: oai:DiVA.org:umu-82442DiVA: diva2:661185