umu.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Universal soldier: Pseudomonas aeruginosa - an opportunistic generalist
Umeå University, Faculty of Science and Technology, Department of Chemistry.
Show others and affiliations
2013 (English)In: Frontiers in Biology, ISSN 1674-7984, Vol. 8, no 4, 387-394 p.Article in journal (Refereed) Published
Abstract [en]

The opportunistic pathogen Pseudomonas aeruginosa commonly causes chronic and ultimately deadly lung infections in individuals with the genetic disease cystic fibrosis (CF). P. aeruginosa is metabolically diverse; it displays a remarkable ability to adapt to and successfully occupy almost any niche, including the ecologically complex CF lung. These P. aeruginosa lung infections are a fascinating example of microbial evolution within a "natural" ecosystem. Initially, P. aeruginosa shares the lung niche with a plethora of other microorganisms and is vulnerable to antibiotic challenges. Over time, adaptive evolution leads to certain commonly-observed phenotypic changes within the P. aeruginosa population, some of which render it resistant to antibiotics and apparently help it to out-compete the other species that co-habit the airways. Improving genomics techniques continue to elucidate the evolutionary mechanisms of P. aeruginosa within the CF lung and will hopefully identify new vulnerabilities in this robust and versatile pathogen. © 2013 Higher Education Press and Springer-Verlag Berlin Heidelberg.

Place, publisher, year, edition, pages
Springer, 2013. Vol. 8, no 4, 387-394 p.
Keyword [en]
adaptive radiation, antibiotic resistance, cystic fibrosis, evolution, Pseudomonas aeruginosa, quorum sensing
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:umu:diva-82585DOI: 10.1007/s11515-013-1267-xOAI: oai:DiVA.org:umu-82585DiVA: diva2:661994
Available from: 2013-11-05 Created: 2013-11-05 Last updated: 2014-01-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Rzhepishevska, OlenaRamstedt, Madeleine

Search in DiVA

By author/editor
Rzhepishevska, OlenaRamstedt, Madeleine
By organisation
Department of Chemistry
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 217 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf