Change search
ReferencesLink to record
Permanent link

Direct link
Cortical responses to single mechanoreceptive afferent microstimulation revealed with fMRI
Karolinska Institute.
University of Nottingham.
University of North Carolina.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Physiology.
Show others and affiliations
2001 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 13, no 4, 613-622 p.Article in journal (Refereed) Published
Abstract [en]

The technique of intraneural microneurography/microstimulation has been used extensively to study contributions of single, physiologically characterized mechanoreceptive afferents (MRAs) to properties of somatosensory experience in awake human subjects. Its power as a tool for sensory neurophysiology can be greatly enhanced, however, by combining it with functional neuroimaging techniques that permit simultaneous measurement of the associated CNS responses. Here we report its successful adaptation to the environment of a high-field MR scanner. Eight median-nerve MRAs were isolated and characterized in three subjects and microstimulated in conjunction with fMRI at 3.0 T. Hemodynamic responses were observed in every case, and these responses were robust, focal, and physiologically orderly. The combination of fMRI with microstimulation will enable more detailed studies of the representation of the body surface in human somatosensory cortex and further studies of the relationship of that organization to short-term plasticity in the human SI cortical response to natural tactile stimuli. It can also be used to study many additional topics in sensory neurophysiology, such as CNS responses to additional classes of afferents and the effects of stimulus patterning and unimodal/crossmodal attentional manipulations. Finally, it presents unique opportunities to investigate the basic physiology of the BOLD effect and to compare the operating characteristics of fMRI and EEG as human functional neuroimaging modalities in an unusually specific and well-characterized neurophysiological setting.

Place, publisher, year, edition, pages
Academic Press, 2001. Vol. 13, no 4, 613-622 p.
Keyword [en]
touch, somatosensory cortex, mechanoreceptive afferent, microneurography, microstimulation, fMRI, EEG
National Category
Neurology Neurosciences Radiology, Nuclear Medicine and Medical Imaging
URN: urn:nbn:se:umu:diva-82651DOI: 10.1006/nimg.2000.0723ISI: 000167628500006PubMedID: 11305890OAI: diva2:662088
Available from: 2013-11-06 Created: 2013-11-06 Last updated: 2014-04-16Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Westling, Göran
By organisation
In the same journal
NeurologyNeurosciencesRadiology, Nuclear Medicine and Medical Imaging

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 27 hits
ReferencesLink to record
Permanent link

Direct link