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Changes in a rat facial muscle after facial nerve injury and repair
University of Linköping.
Umeå University, Faculty of Medicine, Department of Integrative Medical Biology (IMB), Anatomy.
University of Linköping.
University of Linköping.
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2001 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 24, no 9, 1202-1212 p.Article in journal (Refereed) Published
Abstract [en]

This study describes changes in a rat facial muscle innervated by the mandibular and buccal facial nerve branches 4 months after nerve injury and repair. The following groups were studied: (A) normal controls; (B) spontaneous reinnervation by collateral or terminal sprouting; (C) reinnervation after surgical repair of the mandibular branch; and (D) chronic denervation. The normal muscle contained 1200 exclusively fast fibers, mainly myosin heavy chain (MyHC) IIB fibers. In group B, fiber number and fiber type proportions were normal. In group C, fiber number was subnormal. Diameters and proportions of MyHC IIA and hybrid fibers were above normal. The proportion of MyHC IIB fibers was subnormal. Immediate and delayed repair gave similar results with respect to the parameters examined. Group D rats underwent severe atrophic and degenerative changes. Hybrid fibers prevailed. These data suggest that spontaneous regeneration of the rat facial nerve is superior to regeneration after surgical repair and that immediacy does not give better results than moderate delay with respect to surgical repair. Long delays are shown to be detrimental.

Place, publisher, year, edition, pages
John Wiley & Sons, 2001. Vol. 24, no 9, 1202-1212 p.
Keyword [en]
facial muscle, facial nerve injury/repair, muscle fibers, myosin heavy chain, rat
National Category
Neurology
Identifiers
URN: urn:nbn:se:umu:diva-82662DOI: 10.1002/mus.1133ISI: 000170540500012PubMedID: 11494274OAI: oai:DiVA.org:umu-82662DiVA: diva2:662104
Available from: 2013-11-06 Created: 2013-11-06 Last updated: 2017-12-06Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
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  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
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  • Other locale
More languages
Output format
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  • asciidoc
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