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Postural effects on intracranial pressure: modeling and clinical evaluation
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).
Umeå universitet, Medicinska fakulteten, Institutionen för farmakologi och klinisk neurovetenskap, Klinisk neurovetenskap.ORCID-id: 0000-0001-6451-1940
Umeå universitet, Medicinska fakulteten, Institutionen för strålningsvetenskaper, Radiofysik. Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Centrum för medicinsk teknik och fysik (CMTF).
2013 (Engelska)Ingår i: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 115, nr 10, s. 1474-1480Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction The physiological effect of posture on intracranial pressure (ICP) is not well described. This study defined and evaluated three mathematical models describing the postural effects on ICP, designed to predict ICP at different head-up tilt-angles from the supine ICP value.

Methods Model I was based on a hydrostatic indifference point for the cerebrospinal fluid (CSF) system, i.e. the existence of a point in the system where pressure is independent of body position. Models II and III were based on Davson's equation for CSF absorption, which relates ICP to venous pressure, and postulated that gravitational effects within the venous system are transferred to the CSF system. Model II assumed a fully communicating venous system and model III that collapse of the jugular veins at higher tilt-angles creates two separate hydrostatic compartments. Evaluation of the models was based on ICP measurements at seven tilt-angles (0-71°)in 27 normal pressure hydrocephalus patients.

Results ICP decreased with tilt-angle (ANOVA, p<0.01). The reduction was well predicted by model III (ANOVA lack-of-fit: p=0.65), which showed excellent fit against measured ICP. Neither model I nor II adequately described the reduction in ICP (ANOVA lack-of-fit: p<0.01).

Conclusion Postural changes in ICP could not be predicted based on the currently accepted theory of a hydrostatic indifference point for the CSF system, but a new model combining Davson's equation for CSF absorption and hydrostatic gradients in a collapsible venous system performed well and can be useful in future research on gravity and CSF physiology.

Ort, förlag, år, upplaga, sidor
American Physiological Society , 2013. Vol. 115, nr 10, s. 1474-1480
Nyckelord [en]
intracranial pressure, spinal puncture, cerebrospinal fluid pressure, hydrocephalus, normal pressure, pulse pressure waves
Nationell ämneskategori
Medicinteknik
Identifikatorer
URN: urn:nbn:se:umu:diva-82744DOI: 10.1152/japplphysiol.00711.2013ISI: 000327398600008PubMedID: 24052030OAI: oai:DiVA.org:umu-82744DiVA, id: diva2:662783
Forskningsfinansiär
Vetenskapsrådet, 221-2011-5216VINNOVATillgänglig från: 2013-11-08 Skapad: 2013-11-08 Senast uppdaterad: 2018-06-08Bibliografiskt granskad
Ingår i avhandling
1. Analysis of ICP pulsatility and CSF dynamics: the pulsatility curve and effects of postural changes, with implications for idiopathic normal pressure hydrocephalus
Öppna denna publikation i ny flik eller fönster >>Analysis of ICP pulsatility and CSF dynamics: the pulsatility curve and effects of postural changes, with implications for idiopathic normal pressure hydrocephalus
2013 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Alternativ titel[sv]
Analys av ICP-pulsationer och CSF-dynamik : pulsationskurvan och effekter av ändrad kroppsposition, med implikationer för idiopatisk normaltryckshydrocefalus
Abstract [en]

The volume defined by the rigid cranium is shared by the brain, blood and cerebrospinal fluid (CSF). With every heartbeat the arterial blood volume briefly increases and venous blood and CSF are forced out of the cranium, leading to pulsatility in CSF flow and intracranial pressure (ICP). Altered CSF pulsatility has been linked to idiopathic normal pressure hydrocephalus (INPH), which involves enlarged cerebral ventricles and symptoms of gait/balance disturbance, cognitive decline and urinary incontinence that may be improved by implantation of a shunt. The overall aim of this thesis was to investigate the fluid dynamics of the CSF system, with a focus on pulsatility, and how they relate to INPH pathophysiology and treatment.

Mathematical modelling was applied to data from infusion tests, where the ICP response to CSF volume manipulation is measured, to analyse the relationship between mean ICP and ICP pulse amplitude (AMP) before and after shunt surgery in INPH (paper I-II). The observed relationship, designated the pulsatility curve, was found to be constant at low ICP and linear at high ICP, corresponding to a shift from constant to ICP dependent compliance (paper I). Shunt surgery did not affect the pulsatility curve, but shifted baseline ICP and AMP along the curve towards lower values. Patients who improved in gait after surgery had significantly larger AMP reduction than those who did not, while ICP reduction was similar, suggesting that improving patients had baseline ICP in the linear zone of the curve before surgery. Use of this phenomenon for outcome prediction was promising (paper II). The fluid dynamics of an empirically derived pulsatility-based predictive infusion test for INPH was also investigated, with results showing strong influence from compliance (paper III).

Clinical ICP data at different body postures was used to evaluate three models describing postural effects on ICP. ICP decreased in upright positions, whereas AMP increased. The model describing the postural effects based on hydrostatic changes in the venous system, including effects of collapse of the jugular veins in the upright position, accurately predicted the measured ICP (paper IV).

Cerebral blood flow and CSF flow in the aqueduct and at the cervical level was measured with phase contrast magnetic resonance imaging, and compared between healthy elderly and INPH (paper V). Cerebral blood flow and CSF flow at the cervical level were similar in INPH patients and healthy elderly, whereas aqueductal CSF flow differed significantly. The pulsatility in the aqueduct flow was increased, and there was more variation in the net flow in INPH, but the mean net flow was normal, i.e. directed from the ventricles to the subarachnoid space (paper V).

In conclusion, this thesis introduced the concept of pulsatility curve analysis, and provided evidence that pulsatility and compliance are important aspects for successful shunt treatment and outcome prediction in INPH. It was further confirmed that enhanced pulsatility of aqueduct CSF flow was the most distinct effect of INPH pathophysiology on cerebral blood flow and CSF flow. A new model describing postural and hydrostatic effects on ICP was presented, and the feasibility and potential importance of measuring ICP in the upright position in INPH was demonstrated. 

Ort, förlag, år, upplaga, sidor
Umeå: Umeå Universitet, 2013. s. 79
Serie
Umeå University medical dissertations, ISSN 0346-6612 ; 1613
Nyckelord
Cerebrospinal fluid, CSF dynamics, Intracranial pressure, Pulse pressure, Normal pressure hydrocephalus, Posture, Predictive tests, Mathematical modelling, Magnetic resonance imaging, Infusion tests
Nationell ämneskategori
Medicinteknik
Identifikatorer
urn:nbn:se:umu:diva-82784 (URN)978-91-7459-762-2 (ISBN)
Disputation
2013-12-06, Hörsal E 04, Unod R1, Norrlands Universitetssjukhus, Umeå, 13:00 (Engelska)
Opponent
Handledare
Forskningsfinansiär
Vetenskapsrådet, 221-2011-5216Vetenskapsrådet, VR3011-2006-7551Vinnova, VR3011-2006-7551Stiftelsen för strategisk forskning (SSF), VR3011-2006-7551
Anmärkning

Forskningsfinansiär: 

European Union, ERDF: Objective 2, Northern Sweden (grant no. 158715-CMTF). 

Tillgänglig från: 2013-11-15 Skapad: 2013-11-11 Senast uppdaterad: 2018-06-08Bibliografiskt granskad

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