Seroprevalence of Sindbis virus and associated risk factors in northern Sweden
2014 (English)In: Epidemiology and Infection, ISSN 0950-2688, E-ISSN 1469-4409, Vol. 142, no 7, 1559-1565 p.Article in journal (Refereed) Published
Mosquito-borne Sindbis virus (SINV) cause disease characterized by rash, fever and arthritis which often leads to long-lasting arthralgia. To determine the seroprevalence of SINV and associated risk factors in northern Sweden, a randomly selected population aged between 25 and 74 years were invited to join the MONICA study. Serum from 1611 samples were analysed for specific IgG antibodies. Overall, 2·9% had IgG against SINV. More men (3·7%) than women (2·0%) were SINV seropositive (P = 0·047) and it was more common in subjects with a lower educational level (P = 0·013) and living in small, rural communities (P < 0·001). Seropositivity was associated with higher waist circumference (P = 0·1), elevated diastolic blood pressure (P = 0·037), and history of a previous stroke (P = 0·011). In a multiple logistic regression analysis, adjusting for known risk factors for stroke, seropositivity for SINV was an independent predictor of having had a stroke (odds ratio 4·3, 95% confidence interval 1·4–13·0,P = 0·011).
Place, publisher, year, edition, pages
Cambridge University Press, 2014. Vol. 142, no 7, 1559-1565 p.
Arboviruses, epidemiology, risk assessment, Sindbis virus, zoonoses
Infectious Medicine Public Health, Global Health, Social Medicine and Epidemiology
Research subject Medical Virology; Infectious Diseases
IdentifiersURN: urn:nbn:se:umu:diva-82777DOI: 10.1017/S0950268813002239ISI: 000337306100029OAI: oai:DiVA.org:umu-82777DiVA: diva2:663216