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Betamethasone in hernia surgery: a randomized controlled trial
Department of Anesthesiology, Ludvika Hospital, Sweden.
Department of Surgery, Örebro University Hospital, Sweden.
Department of Surgery, Mora Hospital, Sweden.
Department of Surgery, Ludvika Hospital, Sweden.
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2013 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 17, no 10, 1511-1516 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Post-operative pain and nausea may be a problem in day-case surgery. This study aims to investigate the effect of betamethasone on pain and nausea in inguinal hernia surgery.

METHODS: Patients aged 18-70 years scheduled for open inguinal hernia surgery at two Swedish hospitals, March 2005-December 2009, were eligible for inclusion. Patients were randomized, to either treatment with 12 mg betamethasone intravenously or placebo. Post-operative pain was assessed using a visual analogue scale on the recovery ward, each day the first post-operative week and at 1 month after surgery. One year after surgery, residual pain was estimated by the Inguinal Pain Questionnaire.

RESULTS: A total of 398 patients were included (21 women, 377 men). Pain at rest on the day of surgery was significantly lower in the treatment group (p = 0.012). The pain was also significantly lower in the treatment group the day after surgery (p < 0.001), but not during the remaining part of the first post-operative week. Bleeding complications were reported by 17 patients (8.5%) in the Betamethasone group and seven (3.5%) in the placebo group (p = 0.028). One month after surgery, 21 out of 173 (12%) in the betamethasone group still had pain, compared to 33 out of 159 (21%) in the placebo arm (p = 0.049). After 1 year, no significant difference in pain was seen.

CONCLUSION: A 12 mg betamethasone reduced pain during the first 24 h and at 1 month after inguinal hernia surgery. If combined with diclofenac, however, this dose may increase the risk for bleeding complications.

Place, publisher, year, edition, pages
2013. Vol. 17, no 10, 1511-1516 p.
National Category
URN: urn:nbn:se:umu:diva-83434DOI: 10.1002/j.1532-2149.2013.00333.xISI: 000325468000011PubMedID: 23712446OAI: diva2:667132

This study was supported by research grants from the county council of Dalarna and the county council of Örebro, Sweden.

Ingår i avhandling: Magnusson, Niklas. Postoperative aspects of inguinal hernia surgery: pain and recurrences. 2012.

Available from: 2013-11-25 Created: 2013-11-25 Last updated: 2016-09-07Bibliographically approved

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