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Extraocular muscles: Response to neuromuscular diseases and specific pathologies
Umeå University, Faculty of Medicine, Department of Clinical Sciences, Ophthalmology.
2013 (English)In: Craniofacial Muscles: A New Framework for Understanding the Effector Side of Craniofacial Muscle Control / [ed] Linda K. McLoon, Francisco Andrade, New York: Springer-Verlag New York, 2013, 75-90 p.Chapter in book (Refereed)
Abstract [en]

The response of the extraocular muscles (EOMs) to neuromuscular diseases generally differs significantly from that of the other muscles in the body. The EOMs may be early or preferentially affected in diseases such as myasthenia gravis, oculopharyngeal muscular dystrophy (OPMD), and Miller Fisher syndrome (MFS), but in contrast they remain notoriously unaffected in the muscle dystrophies originating from defects in the dystrophin–glycoprotein complex (DGC). Accumulating evidence points towards a special response of the EOMs in ALS, also distinct from that of the other striated muscles in the body. From a clinical point of view, it is important to realize that even very small disturbances of ocular motility have a great impact on visual function and quality of life. We rely upon perfect coordination of eye movements to align both foveas properly and send a single coherent image to the brain. The EOMs are the effector organ for ocular motility.

Place, publisher, year, edition, pages
New York: Springer-Verlag New York, 2013. 75-90 p.
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URN: urn:nbn:se:umu:diva-83505DOI: 10.1007/978-1-4614-4466-4_5ISBN: 9781461444657OAI: diva2:668005
Available from: 2013-11-28 Created: 2013-11-28 Last updated: 2014-03-27Bibliographically approved

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