Progression of attachment loss is strongly associated with presence of the JP2 genotype of Aggregatibacter actinomycetemcomitans: a prospective cohort study of a young adolescent population
2014 (English)In: Journal of Clinical Periodontology, ISSN 0303-6979, E-ISSN 1600-051X, Vol. 41, no 3, 232-241 p.Article in journal (Refereed) Published
AIM: To assess the progression of attachment loss (AL) during a two-year period according to the presence of JP2 and non-JP2 genotypes of A. actinomycetemcomitans in a Ghanaian adolescent population.
METHODS: A total of 500 adolescents (mean age 13.2 years, SD± 1.5) were enrolled in the study. After two years, 397 (79.4%) returned for a periodontal re-examination, including the measurement of AL. The carrier status of the JP2 and non-JP2 genotypes of A. actinomycetemcomitans was evaluated in a baseline examination two years earlier.
RESULTS: Individuals who carried the JP2 genotype of A. actinomycetemcomitans had a significantly increased risk (relative risk (RR) = 7.3) of developing AL ≥ 3 mm. The mean AL at the follow-up and the mean two-year progression of AL was significantly higher in the JP2 genotype-positive group (n=38) compared with the group positive for the non-JP2 genotypes of A. actinomycetemcomitans (n=169), and the group of A. actinomycetemcomitans-negative individuals (n=190). The JP2 genotype was strongly associated with the progression of AL ≥ 3 mm (OR= 14.3). The non-JP2 genotypes of A. actinomycetemcomitans were also, however less pronounced, associated with the progression of AL ≥ 3 mm (OR=3.4).
CONCLUSION: The JP2 genotype of A. actinomycetemcomitans is strongly associated with the progression of AL.
Place, publisher, year, edition, pages
2014. Vol. 41, no 3, 232-241 p.
A. actinomycetemcomitans, JP2 genotype, attachment loss, progression, leukotoxin, Ghana, periodontitis, adolescent
Research subject Infectious Diseases
IdentifiersURN: urn:nbn:se:umu:diva-83805DOI: 10.1111/jcpe.12209ISI: 000330577300003PubMedID: 24304011OAI: oai:DiVA.org:umu-83805DiVA: diva2:676974
FunderSwedish Research Council