Change search
ReferencesLink to record
Permanent link

Direct link
Association Between Circulating Endostatin, Hypertension Duration, and Hypertensive Target-Organ Damage
Umeå University, Faculty of Medicine, Department of Surgical and Perioperative Sciences, Surgery.
Show others and affiliations
2013 (English)In: Hypertension, ISSN 0194-911X, E-ISSN 1524-4563, Vol. 62, no 6, 1146-1151 p.Article in journal (Refereed) Published
Abstract [en]

Our aim is to study associations between circulating endostatin, hypertension duration, and hypertensive target-organ damage. Long-term hypertension induces cardiovascular and renal remodeling. Circulating endostatin, a biologically active derivate of collagen XVIII, has been suggested to be a relevant marker for extracellular matrix turnover and remodeling in various diseases. However, the role of endostatin in hypertension and hypertensive target-organ damage is unclear. Serum endostatin was measured in 2 independent community-based cohorts: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; women 51%; n=812; mean age, 75 years) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n=785; mean age, 77.6 years). Retrospective data on blood pressure measurements and antihypertensive medication (PIVUS >5 years, ULSAM >27 years), and cross-sectional data on echocardiographic left ventricular mass, endothelial function (endothelium-dependent vasodilation assessed by the invasive forearm model), and urinary albumin/creatinine ratio were available. In PIVUS, participants with 5 years of history of hypertension portrayed 0.42 SD (95% confidence interval, 0.23-0.61; P<0.001) higher serum endostatin, compared with that of normotensives. This association was replicated in ULSAM, in which participants with 27 years hypertension duration had the highest endostatin (0.57 SD higher; 95% confidence interval, 0.35-0.80; P<0.001). In addition, higher endostatin was associated with higher left ventricular mass, worsened endothelial function, and higher urinary albumin/creatinine ratio (P<0.03 for all) in participants with prevalent hypertension. Circulating endostatin is associated with the duration of hypertension, and vascular, myocardial, and renal indices of hypertensive target-organ damage. Further studies are warranted to assess the prognostic role of endostatin in individuals with hypertension.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2013. Vol. 62, no 6, 1146-1151 p.
Keyword [en]
angiogenesis effects, antiangiogenesis effects, cohort study, endothelial cells, epidemiology, extracellular matrix, Sweden, vascular stiffness
National Category
Cardiac and Cardiovascular Systems
URN: urn:nbn:se:umu:diva-83887DOI: 10.1161/HYPERTENSIONAHA.113.02250ISI: 000326919300036OAI: diva2:678534
Swedish Research Council, 20066555, 2012-1727, 2012-2215Swedish Heart Lung FoundationMarianne and Marcus Wallenberg Foundation
Available from: 2013-12-12 Created: 2013-12-10 Last updated: 2013-12-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Ruge, Toralph
By organisation
In the same journal
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 50 hits
ReferencesLink to record
Permanent link

Direct link