Change search
ReferencesLink to record
Permanent link

Direct link
The migration of cerebellar rhombic lip derivatives.
Umeå University, Faculty of Medicine, Department of Pharmacology and Clinical Neuroscience, Clinical Neuroscience.
Show others and affiliations
2002 (English)In: Development, ISSN 0950-1991, E-ISSN 1477-9129, Vol. 129, no 20, 4719-4728 p.Article in journal (Refereed) Published
Abstract [en]

We have used cell labelling, co-culture and time-lapse confocal microscopy to investigate tangential neuronal migration from the rhombic lip. Cerebellar rhombic lip derivatives demonstrate a temporal organisation with respect to their morphology and response to migration cues. Early born cells, which migrate into ventral rhombomere 1, have a single long leading process that turns at the midline and becomes an axon. Later born granule cell precursors also migrate ventrally but halt at the lateral edge of the cerebellum, correlating with a loss of sensitivity to netrin 1 and expression of Robo2. The rhombic lip and ventral midline express Slit2 and both early and late migrants are repelled by sources of Slit2 in co-culture. These studies reveal an intimate relationship between birthdate, response to migration cues and neuronal fate in an identified population of migratory cells. The use of axons in navigating cell movement suggests that tangential migration is an elaboration of the normal process of axon extension.

Place, publisher, year, edition, pages
2002. Vol. 129, no 20, 4719-4728 p.
Keyword [en]
chick, netrin, slit; Robo, GFP, time-lapse confocal microscopy
National Category
Developmental Biology
URN: urn:nbn:se:umu:diva-84176DOI: 10.12688/f1000research.2-148.v1ISI: 000179000300006PubMedID: 12361964OAI: diva2:679869
Available from: 2013-12-16 Created: 2013-12-16 Last updated: 2014-02-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Gilthorpe, JonathanPapantoniou, Elli-KalliopiChédotal, AlainLumsden, AndrewWingate, Richard J T
By organisation
Clinical Neuroscience
In the same journal
Developmental Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 14 hits
ReferencesLink to record
Permanent link

Direct link